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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

1398 - Clinical utility of hepatic arterial infusion chemotherapy for heavily pretreated metastatic breast cancer patients: A review of a single institution

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

Mitsuhiro Furuta

Citation

Annals of Oncology (2018) 29 (suppl_8): viii90-viii121. 10.1093/annonc/mdy272

Authors

M. Furuta1, J. Watanabe1, T. Aramaki2

Author affiliations

  • 1 Division Of Breast Oncology, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
  • 2 Division Of Radiology, Shizuoka Cancer Center, 411-8777 - Shizuoka/JP
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Resources

Abstract 1398

Background

Liver metastasis is recognized as a risk factor for metastatic breast cancer (MBC). Hepatic arterial infusion chemotherapy (HAIC) is a treatment option for MBC in patients with extensive hepatic lesions; however, there is no standard regimen, and the effects have not been well discussed.

Methods

We reviewed our medical records of MBC to extract patients with resistance to standard systemic chemotherapies, critical liver metastasis, and who received HAIC with an FEM regimen (5-fluorouracil 333 mg/m2 [weekly], epirubicin 30 mg/m2 [every 4 weeks], and mitomycin-C 2.7mg/m2 [every 2 weeks]) in our institute.

Results

We identified 58 patients who received HAIC (median age at initiation, 58 [30-80] years) in our institute between 2002 and 2017. Their ECOG performance (PS) statuses were as follows: PS0, 44; PS1, 10; and PS 2, 4. Their receptor statuses were as follows: hormone receptor positive (HR+)/HER2+, 9; HR+/HER2-, 38; HR-/HER2+, 4; HR-/HER2-, 7. The median number of systemic regimens (including endocrine therapy) prior to HAIC was 6 (2-17). The median number of liver metastases was 8 (1-≥20); the median maximum size of liver metastases was 5.2 cm (1.6-20.1). The median number of extrahepatic metastatic site was 2 (0-5). The median overall survival (days) was as follows: overall, 371 (95% confidence interval [CI] 260-475); HER2+, 441 (95% CI 166-652); HER2-, 344 (95% CI 279-475). The median time to progression of intrahepatic lesions (days) was as follows: overall, 303 (95% CI 184-491); HER2+, 491 (95% CI 90-NR); HER2-, 298 (95% CI 184-387). An objective response (CR+PR) of intrahepatic lesions was observed in 37 patients (63.8%). The reasons for the discontinuation of HAIC included: progression of extrahepatic lesion(s), 20 (34.5%); progression of intrahepatic legion(s), 16 (27.6%); clinical progression, 7 (12.1%); transition to maintenance therapy, 6 (10.3%); catheter-related events, 5 (8.6%); and duodenal ulcer, 1 (1.7%).

Conclusions

HAIC with an FEM regimen offers an effective treatment for patients with liver metastasis from MBC that shows resistance to systemic therapy.

Clinical trial identification

Legal entity responsible for the study

Junichiro Watanabe.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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