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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

1438 - A multicenter retrospective investigation on the efficacy of perioperative oral management in cancer patients

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

Shin-ichi Yamada

Citation

Annals of Oncology (2018) 29 (suppl_8): viii603-viii640. 10.1093/annonc/mdy300

Authors

S. Yamada1, S. Soutome2, T. Hasegawa3, I. Toujou4, H. Nakahara5, M. Kawakami6, M. Hirose7, S. Fujita4, T. Komori3, T. Kirita6, Y. Shibuya7, M. Umeda2, H. Kurita1

Author affiliations

  • 1 Department Of Dentistry And Oral Surgery, Shinshu University, School of Medicine, 390-8621 - Matsumoto/JP
  • 2 Department Of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki/JP
  • 3 Department Of Oral And Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe/JP
  • 4 Department Of Oral And Maxillofacial Surgery, Wakayama Medical University, Wakayama/JP
  • 5 Department Of Dentistry And Oral Surgery, Osaka City University Graduate School of Medicine, Osaka/JP
  • 6 Department Of Oral And Maxillofacial Surgery, Nara Medical University, Kashihara/JP
  • 7 Department Of Oral And Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya/JP
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Resources

Abstract 1438

Background

Patients suffer from various oral complications in cancer treatments. Oral bacteria associate with the onset of dental focal infections and the progression of oral mucositis. Moreover, dental focal infections frequently associate with the onset of bacteremia, sepsis, and pneumonia systemically. The oral function degeneracy with these complications may become obstacle in cancer treatments. In Japan, the comprehensive oral management, including oral care and removal of dental focal infections, are performed in cancer patients. The aim of present study was to investigate the incidence of dental/oral complications in the cancer patients who underwent perioperative oral managements (POMs) based on large number of case series with a multicenter retrospective analysis.

Methods

In cancer patients who underwent POMs, medical records were reviewed and the incidence of oral complications and the efficacy of oral management were investigated retrospectively. This study protocol was approved by the Committee on Medical Research of Shinshu University (♯3639).

Results

Two thousand seven hundred and forty-four cancer patients underwent POMs (1,684 males and 1080 females, mean age 65.9±13.0 years) were investigated in this study. Among 2,744 patients, 2,097 patients (76.4%) started POMs before the initiation of cancer treatment, in which 2,130 patients (77.6%) underwent only oral care, and 391 patients (14.2%) invasive treatment such as tooth extraction. The incidence of dental focal infections during the period of cancer treatment was 8.2%. Acute periodontitis including alveolar abscess was most frequently seen (112 patients, 4.1%). The incidence of grade 2 and 3 oral mucositis was 2.8%. And the fever of unknown origin was seen in 113 patients (4.1%). Among them, dental focal infections were proved to be associated in 7 cases (6.2%). These incidences were thought to be lower than those of previously reports.

Conclusions

The efficacy of oral management in cancer patients might be suggested based on the analysis of large number of patients in this study. However, the further investigation is needed to establish the adequate oral management guideline in cancer patients.

Clinical trial identification

Nothing.

Legal entity responsible for the study

The Committee on Medical Research of Shinshu University.

Funding

Has not received any funding.

Editorial Acknowledgement

Nothing.

Disclosure

All authors have declared no conflicts of interest.

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