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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

6101 - +405C>G polymorphism of VEGF in randomly selected GBM patients

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Topics

Targeted Therapy

Tumour Site

Central Nervous System Malignancies

Presenters

Igor Djan

Citation

Annals of Oncology (2018) 29 (suppl_8): viii122-viii132. 10.1093/annonc/mdy273

Authors

I. Djan1, M. Djan2, N. Vucinic3, B. Nikolin4, S. Salma4, S. Lucic5, N. Vuckovic6, M. Lucic7

Author affiliations

  • 1 Department Of Radiotherapy, Oncology Institute of Vojvodina, 21204 - Sremska Kamenica/RS
  • 2 Department Of Biology And Ecology, University of Novi Sad Faculty of Sciences, Novi Sad/RS
  • 3 Department Of Pharmacy, University of Novi Sad Faculty of Medicine, Novi Sad/RS
  • 4 Department Of Medical Oncology, Oncology Institute of Vojvodina, 21204 - Sremska Kamenica/RS
  • 5 Department Of Nuclear Medicine, Oncology Institute of Vojvodina, 21204 - Sremska Kamenica/RS
  • 6 Department Of Pathology, University of Novi Sad Faculty of Medicine, Novi Sad/RS
  • 7 Diagnostic Imaging Center, Oncology Institute of Vojvodina, 21204 - Sremska Kamenica/RS
More

Resources

Abstract 6101

Background

Vascular endothelial growth factor (VEGF) is a glycoprotein growth factor specific for vascular endothelial cells, responsible for angiogenesis. So far, 44 SNPs with clinical relevance have been detected (ClinVar NCBI database) and the majority of those are associated with cancers of colon and others solid tumors. The aim of this study was to assess the distribution of + 405C>G VEGF gene polymorphism in patients diagnosed with glioblastoma and to test association with the overall survival.

Methods

Tissue paraffin-embedded samples were subjected to molecular analyses and VEGF polymorphism detection retrieved from 66 patients diagnosed for glioblastoma. VEGF genotypes at position

Results

The most frequent allele (SNP variant) was G (72.58%) (Table). No statistically significant differences were observed in a pairwise genotype groups comparison for overall survival (OS). Between-group variance is negative (-3,840), indicating no differences in mean OS among genotypes. ANOVA also did not show any statistically significant variance among groups (F = 0.124; p = 0.879).Table: 390P

Descriptive statistics for overall survival in three genotypes of VEGF gene

GenotypeNMean OSSDSECI (95%)
lowerupper
CC910.568.9182.9733.7017.41
CG3211.009.4491.6707.5914.41
GG2112.108.4201.8378.2615.93
Total6211.318.9101.1329.0413.57

N – number of patients; OS – overall survival in months; SD – standard deviation; SE – standard error; CI – confidence interval; min – minimum in months; max – maximum in month

Conclusions

Even though no significant difference in overall survival in GBM patients regarding the examined polymorphism of VEGF gene was found, it was also shown that genotype GG has one month longer overall survival in the examined patients group. It is probable that random selection of patients regardless of applied treatment, or without treatment, and ECOG 1-4 requires larger number of patients to be included in order to provide final proof whether this polymorphism has any effect on overall survival.

Clinical trial identification

Legal entity responsible for the study

Milos Lucic.

Funding

Provincial Secretariat for High Education and Science of Vojvodina Province.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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