Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

3364 - Young-onset gastric cancer - The role of microbial factors


09 Sep 2017


Poster display session


Cancers in Adolescents and Young Adults (AYA);  Gastric Cancer


Irit Ben-Aharon


Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369


I. Ben-Aharon1, A. Moore1, E. Hikri2, T. Goshen-Lago1, T. Lazar2, H. Kashtan3, B. Brenner1

Author affiliations

  • 1 Oncology, Rabin Medical Center, 49100 - Petah Tikva/IL
  • 2 Cell Biology, Tel-Aviv University, 49100 - Tel-Aviv/IL
  • 3 Surgery, Rabin Medical Center, 49100 - petach tikva/IL


Abstract 3364


Gastric cancer (GC) is a leading cause of cancer death, associated with environmental and genetic factors, with increasing incidence in young patients. Recently, as part of the Cancer Genome Atlas (TCGA) project, a comprehensive molecular characterization of gastric adenocarcinoma revealed unique molecular and genetic patterns that were classified GC into four subtypes among which is the Epstein-Barr Virus (EBV)-associated subtype. The EBV-associated subtype is positive for the virus, displays unique genomic landscape and represents 8.7% of the cohort of the TCGA. Since most of the young-onset GC is sporadic and non-hereditary upon former studies, environmental factors may play a role in the pathogenesis of GC among young patients. We hypothesized that the prevalence of EBV-subtype may be higher in young-onset GC than in the average-onset.


Tissue tumor samples of matched cohorts of young-onset (60y) were retrospectively retrieved, DNA was extracted and analyzed by quantitative PCR (qPCR) for EBV using two different EBNA primers to validate the detection of the virus. Clinical data among which patient demographics, tumor location and family history were extracted from medical records and correlated to age.


Twenty-nine young-onset GC patients and 34 average-onset GC patients were enrolled into the study. Median age for the young-onset was 34y (range 21-45) and for the average-onset 69y (60-90). Thirty-six percent of the young-onset were male, compared with 57% in the average-onset. Family history was more prevalent in the average-onset cohort (37% vs. 29%). The distribution of the tumor location differed between the two groups – whereas in the young-onset 36% of the tumors were in the body of the stomach compared with 46% of the average-onset that were in the antrum. EBV was significantly more prevalent in the young-onset cohort (32.1% compared with 11.4% in the average-onset).


Our study indicate that EBV may play a key role in the pathogenesis of young-onset GC. Since young-onset GC is not predominated by hereditary factors, environmental and microbial factors should be further studied as essential contributors, what may potentially govern early detection in high risk populations.

Clinical trial identification

Legal entity responsible for the study

Irit Ben-Aharon




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.