Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

1145 - What are the treatment patterns and overall survival (OS) in patients with metastatic triple-negative breast cancer (mTNBC) in US clinical practice?


11 Sep 2017


Poster display session


Breast Cancer


Preeti Bajaj


Annals of Oncology (2017) 28 (suppl_5): v74-v108. 10.1093/annonc/mdx365


P. Bajaj1, D. Latremouille-Viau2, A. Guerin2, C. Reyes1, A. Stein1, A. Kurian3, P. Cortazar1

Author affiliations

  • 1 Us Medical Affairs, Genentech Inc. - Roche - USA, 94080 - South San Francisco/US
  • 2 Analysis Group, Analysis Group, H3B 4W5 - Montreal/CA
  • 3 Division Of Oncology, Stanford University School of Medicine, 94305 - Stanford/US


Abstract 1145


mTNBC is a condition with significant unmet medical need due to limited treatment (tx) options and short survival after chemotherapy (chemo) failure. Tx patterns and OS in patients (pts) with mTNBC in US clinical practice were assessed.


This retrospective chart review study used data collected in October and November 2016 from US oncologists via an online case report form. Data of adult pts who were initiated on a pharmacological tx after a diagnosis of recurrent or de novo mTNBC between January 2012 and June 2015 were reviewed. Tx regimens used in 1st- and 2nd-lines for mTNBC were summarized. Median OS from 1st- and 2nd-line tx initiation were estimated using Kaplan-Meier analyses.


125 oncologists provided data on 411 mTNBC pts; mean age was 57 years; 298 (73%) had ≥2 lines of tx; 256 different tx sequences were identified. Mean duration of tx was 7.5 months (mos) in 1st-line and 7.3 mos in 2nd-line. The most prevalent tx regimens were single agent chemo with taxane (22%) in 1st-line and capecitabine (Cap; 20%) in 2nd-line. Median OS was 16.7 mos in 1st-line and 14.2 mos in 2nd-line.Table:


1st-line, N = 411%Median OS [95% CI], mos
All-16.7 [15.2; 18.0]
Single agent4515.6 [13.2; 18.6]
Combination5517.0 [15.1; 19.1]
Tx regimen
Single agent taxane (docetaxel/paclitaxel (pac)/nab-pac)22
Anthracycline (ATC; doxorubicin [Dox]/epirubicin/liposomal Dox) + cyclophosphamide +/- taxane14
Platinum (carboplatin/cisplatin/oxaliplatin) + taxane13
Gemcitabine (Gem) + platinum10
2nd-line, N = 298
All-14.2 [10.5; 22.3]
Single agent7212.9 [10.5; 22.3]
Combination2816.2 [8.1; -]
Tx regimen
Platinum-containing (w/o taxane)13
Single agent taxane13
Taxane-containing combination12
ATC-containing (w/o taxane or platinum)8


Findings suggest that, in US clinical practice, there is substantial heterogeneity in the tx of pts with mTNBC. Pts had a median OS 

Clinical trial identification

Legal entity responsible for the study

Genentech, Inc.


Genentech, Inc.


P. Bajaj, C. Reyes, A. Stein, P. Cortazar: Employee of Genentech, Inc. and owner of Roche stock. D. Latremouille-Viau, A. Guerin: Employee of Analysis Group, Inc., which has received consulting fees and research funding from Genentech, Inc. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.