Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

3605 - Updated results of the Breast cancer task force phase II study of neoadjuvant weekly carboplatin (Cp) added to paclitaxel (P) followed by epirubicin (E) and cyclophosphamide (C) in triple negative breast cancer (TNBC) patients (pts).

Date

11 Sep 2017

Session

Poster display session

Topics

Cytotoxic Therapy;  Breast Cancer

Presenters

Christel Fontaine

Citation

Annals of Oncology (2017) 28 (suppl_5): v43-v67. 10.1093/annonc/mdx362

Authors

C. Fontaine1, N. Cappoen1, V. Renard2, H. Van Den Bulk3, P. Vuylsteke4, P. Glorieux5, L. Decoster6, M. Vanhoeij7, J. De Grève6, A. Awada8, H. Wildiers9

Author affiliations

  • 1 Medische Oncologie, UZ Brussels, 1090 - Jette/BE
  • 2 Medische Oncologie, AZ st Lucas, 9000 - Gent/BE
  • 3 Medische Oncologie, Imelda ZH, 2820 - Bonheiden/BE
  • 4 Medische Oncologie, St Elisabeth, 5000 - Namur/BE
  • 5 Medische Oncologie, Cliniques Sud Luxembourg, 6700 - Arlon/BE
  • 6 Medische Oncologie, UZ Brussel, 1090 - Jette/BE
  • 7 Oncologische Heelkunde, UZ Brussel, 1090 - Jette/BE
  • 8 Medical Oncology, Jules Bordet, 1000 - Brussel/BE
  • 9 General Medical Oncology, University Hospitals Leuven, 3000 - Leuven/BE
More

Resources

Abstract 3605

Background

Introduction: TNBC has the highest mortality of all BC subtypes. Neoadjuvant platinum added to the taxanes-antracycline chemotherapy has been reported to improve pathologic complete response (pCR) rate and survival in TNBC. Aim: To evaluate the efficacy and toxicity of the addition of weekly Cp to Pl and dose dense EC on the pCR rate in an open-label phase II study in stage II/III TNBC pts.

Methods

Patients and methods: Sixty three pts received dose dense P (80mg/m2/wk) concurrent with Cp (AUC=2) for 12 wks, added to two-weekly E (90mg/m2) and C (600mg/m2) for 4 cycles, and followed by surgery and radiotherapy. The primary endpoint was pCR in the breast and axilla. Additionally adverse events are registered. A correlative assessment of germ line mutations in HRD genes is ongoing. Pts are monitored for clinical response by magnetic resonance and mammography and also for relapse free survival and time to treatment failure. The study sample size has been calculated according to the optimal Simon’s two-stage design method. The target sample size was 63 patients with 80% power to detect a pCR rate of > or = 47% (α = 0.05).

Results

Accrual to the study is completed and 63 eligible pts with operable, non-inflammatory stage II/III TNBC were included. Most pts were between 40 and 60 yr old and 49 out of 63 were stage T2. Forty percent were clinically node + and 68% were G3. Seventy three percent received breast conserving surgery. Thirty eight out of 63 pts (60%) achieved a pCR rate in the breast and axilla. In 52 evaluable pts for toxicity, the main toxicity for part 1 (Cp+P) of the combination was neutropenia G3/4 in 37 pts (71%) and for part 2 (EC) febrile neutropenia G3/4 in 18 pts (34%) despite primary prophylaxis, followed by thrombocytopenia G3/4 in 11 pts (21%). Only three pts had a neuropathy G3.

Conclusions

The addition of weekly carboplatinum to neoadjuvant dose dense paclitaxel and EC is feasible and a pCR rate in the breast and axilla as high as 60% in early TNBC pts is obtained. Correlation with genomic HRD deficiency is ongoing.

Clinical trial identification

2014-003723-21; 28-02-2014

Legal entity responsible for the study

Breast Cancer Task force on behalf of the BSMO (Belgian Society of Medical Oncology)

Funding

Amgen and Teva

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.