Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

2209 - Triple Negative Breast Cancer: 10-year Survival Update of The Applied Treatment Strategy in Kuwait


11 Sep 2017


Poster display session


Breast Cancer


M.Salah Fayaz


Annals of Oncology (2017) 28 (suppl_5): v68-v73. 10.1093/annonc/mdx364


M.S. Fayaz1, G. Demian2, M. El-Sherify3, M. Aziz1, H. Eissa2

Author affiliations

  • 1 Radiation Oncology, Kuwait Cancer Control Centre Al Sabah Hospital, 70653 - Shuwaikh/KW
  • 2 Radiation Oncology, National Cancer Institute, Cairo University, 9999 - Cairo/EG
  • 3 Radiation Oncology Department, Kuwait Cancer Control Center, NA - Kuwait/KW


Abstract 2209


Triple negative breast cancer (TNBC) is recognized as a distinct clinical and biological entity of poor outcome for almost two decades, yet its treatment strategy still needs to be better specified. The study aim is to update the 10-year survival data of our TNBC patients and to find its association with different applied treatment modalities.


We updated 10-year survival data of 359 women diagnosed with TNBC between 1999 and 2009 in Kuwait Cancer Control Center (KCCC). The overall survival (OS), disease free survival (DFS), distant metastasis free survival (DMFS) and loco-regional free survival (LRFS) were estimated using Kaplan Meier method. Survival was correlated with different prognostic factors and treatment modalities. Statistical significance was calculated using the log-rank test and defined as p < 0.05. Cox regression was used for Multivariate analysis.


TNBC represented 12% of breast cancer in Kuwait with a median age of 48 years. The stage distribution was as follow: stage I, II, III, IV in 15%, 43%, 35% and 7% of patients respectively. Regarding surgery, 33% had Conservative surgery; 67% had mastectomy and 82% had axillary clearance. Chemotherapy was neoadjuvant in 25%, adjuvant in 56% and palliative in 5% of patients. Two-thirds of patients (67%) received adjuvant radiotherapy. After a median follow-up of 108 months, the 10-year OS, DFS, DMFS and LRFS were 66%, 59%, 72% and 77% respectively. The 10-year OS was 92%, 80%, 49% and 0% for Stage I,II,III and IV respectively (p = 0.0000). OS was significantly worse with the presence of lymphovascular invasion (LVI; p = 0.003). OS was not significantly affected by age, grade or treatment modality. In multivariate analysis, the clinical stage and LVI were still significant (P = 0.0000 and 0.04 respectively).


In absence of biological biomarkers, the clinical stage and LVI seems to be the only significant prognostic factors for survival of TNBC patients in our study population. Timing of chemotherapy as well as the extent of surgery do not seem to affect the TNBC patients' outcome.

Clinical trial identification

Legal entity responsible for the study





All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.