Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

3933 - Thromboembolic complications in patients with oesophagogastric adenocarcinoma undergoing preoperative chemotherapy

Date

09 Sep 2017

Session

Poster display session

Topics

Supportive Care and Symptom Management;  Therapy;  Oesophageal Cancer;  Gastric Cancer

Presenters

Theodora Germetaki

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

T. Germetaki1, K. Kamposioras2, G. Papaxoinis1, J. Weaver1, S. Galloway3, S. Stamatopoulou1, M. Nasralla1, Z. Kordatou1, A. Anthoney4, W. Mansoor1

Author affiliations

  • 1 Medical Oncology, The Christie NHS Foundation Trust, M20 4BX - Manchester/GB
  • 2 Medical Oncology, The Mid Yorkshire Hospitals NHS Trust-Pinderfields General Hospital, WF1 4DG - Wakefield/GB
  • 3 Oesophago-gastric Surgery, University Hospital of South Manchester, M23 9LT - Manchester/GB
  • 4 Medical Oncology, The Leeds Teaching Hospitals NHS Trust, LS9 7TF - Leeds/GB
More

Resources

Abstract 3933

Background

The scope of the present study was: to describe the incidence of thromboembolic events (TE) in patients (pts) with resectable oesophagogastric (OG) adenocarcinoma receiving preoperative chemotherapy (CT) with curative intent; to assess risk factors of developing TE; to determine their impact on patient outcome.

Methods

Data from 590 pts with OG adenocarcinoma, who received epirubicin, cisplatin and capecitabine (ECX) or 5-fluorouracil (ECF) preoperatively in 3 UK hospitals, between 2009 & 2016, were collected retrospectively.

Results

Median age was 66 years (range 28-85), 81% were males, 21% had gastric primaries, 98% received ECX chemotherapy, and 87% completed all 3 cycles of preoperative CT. In total, 52 pts (9%) had a venous and 22 (4%) an arterial event. Of patients with venous TE, 39 had pulmonary embolism and 13 deep vein thrombosis. Of patients with arterial TE, 7 developed cardiac infarct, 8 limb ischemia, 4 cerebrovascular accident and 3 superior mesenteric artery thrombosis. Arterial TE was associated with much higher inoperability rate compared to cases with venous TE or without TE (77% vs. 31% vs. 20% respectively, p 

Conclusions

Preoperative ECX/ECF chemotherapy for patients with resectable OG adenocarcinoma was associated with relatively high incidence of TE. However, only arterial TE affected patient outcome

Clinical trial identification

Legal entity responsible for the study

Wasat Mansoor

Funding

None

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.