In this study, the prognostic role of HMGB expression determined with immunohistochemistry in patients with glioblastoma, and the relationship with the systemic inflammatory response indicators, NLR and PLR are studied.
This study included 30 patients who had a histopathologic diagnosis of glioblastoma and 14 patients who underwent surgery for a non-tumoural intracranial pathology in Antalya Education and Research Hospital between 2008-2012. HMGB1 expression was examined via immunohistochemical method.
There were a significant difference of HMGB1 expression between the study and the control group (p = 0.002). HMGB1 expression was found positive in 23 patients (76.7%) and negative in 7 (23.3%) patients in the study group. In the control group, it was positive in 4 (28.6%) patients and negative in 10 (71.4%) patients. When NLR was used as the SIR indicator, it was determined as positive in 11 (36.7%) patients and as negative in 19 (63.3%) patients. When PLR was used as the SIR indicator, it was determined as positive in 10 (33.3%) patients and negative in 20 (66.7%) patients. Median follow up period of patients was 7.8±7.2 (Range 0.7-26.1). Median survival of the study group was 9.6±1.8 (95% Confidence Interval Range 6-13.2) (Figure 1). There wasn’t any significant difference between HMGB1 expression and survival (p = 0.692) (Figure 2). When NLR or PLR was used as the SIR indicator, there wasn’t any relation or difference determined between SIR and survival (p = 0.692, p = 0.740). A significant relation was determined between HMBG1 expression and NLR (p = 0.29). NLR was negative in 17 (73.9%) patients with positive HMGB1 expression, whereas it was negative in 2 (28.6%) patients with negative HMGB1 expression. HMGB1 expression suppresses SIR response. There wasn't any relationship between HMGB1 expression and PLR (p = 0,127).
Results we achieved in our study lead to the opinion that HMGB1 overexpression might have a role in the immune response to the developing tumour in patients with glioblastoma. While treatment strategies are developing in patients with glioblastoma, we believe that HMGB1 could be an important treatment goal.
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All authors have declared no conflicts of interest.