Glioblastoma is the most common primary malignant brain tumor in adults. Despite of postoperative adjuvant therapy, glioblastoma recurs in almost all the patients. After recurrence, chemotherapy, carmustine wafer intended for lesions, usage of anti-VEGF, re-operation, re-irradiation are the existent salvage therapy options. In this meta-analysis, the prognostic role of age in Salvage re-irradiation applied patients with recurrence glioblastoma was analyzed.
PubMed and EBSCOhost databases are searched for malignant glioma, high-grade glioma, recurrence, survival, re-irradiation, re- radiation. Browsing databases was done in English.
1588 patients were included to meta-analysis. Pooled hazard ratio showed that overall survival is correlated with re-operation (HR,1.042; 95% CI, 1.012-1.073; p:0,006). Pooled hazard ratio was calculated by using fixed effect model. The quality determinations of 4 studies were done by using Newcastle-Ottowa Scale. The studies were counted low quality with the score 1-3, average quality with the score 4-6, high quality with the score7-9. Median score of the studies was calculated as 5.
In this meta-analysis, we showed that for re-irradiation treatment, which is a salvage therapy option for recurrent glioblastoma, the age is an important prognostic factor.
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All authors have declared no conflicts of interest.