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Poster display session

2764 - The preventive role of intravenous L-alanyl L-Glutamine in reducing the incidence of oral mucositis in head and neck cancer patients receiving radiotherapy with or without chemotherapy

Date

10 Sep 2017

Session

Poster display session

Topics

Supportive Care and Symptom Management;  Head and Neck Cancers

Presenters

Amany Elfeky

Citation

Annals of Oncology (2017) 28 (suppl_5): v543-v567. 10.1093/annonc/mdx388

Authors

A.M. Elfeky, N. Sabry, A. Barakat

Author affiliations

  • Clinical Oncology And Nuclear Medicine, Tanta University Hospital, 31511 - Tanta/EG
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Resources

Abstract 2764

Background

The current prospective comparative phase 2 study aimed to assess the role of intravenous L-alanyl L-Glutamine in reducing the rate of oral mucositis for squamous head and neck cancer patients receiving radiotherapy with or without concurrent chemotherapy.

Methods

From September 2014 to Septemper 2016, 100 head and neck cancer patients were treated with radiotherapy or combined chemo-radiation at the Clinical Oncology Department, Tanta University Hospitals. Patients were randomized in 1:1 ratio into Group A (n = 50 patients) treated by radiotherapy or concurrent chemo-radiotherapy and Group B (n = 50 patients) to receive same treatment in addition to intravenous Glutamine. The investigational drug was infused daily at dose of 0.3-0.4 g/kg diluted in NS and administered at rate of 0.1g/Kg/hr. All patients received total dose of 65-70 Gy using Linac 6MV photon beam supplemented with electron beam when needed. For concurrent chemotherapy, Cisplatin (40mg/m2) was administered weekly.

Results

Mucositis was assessed by WHO grading system. A significantly higher incidence of mucositis was reported in 45% of Group A patients compared with patients in group B who received glutamine 10% P 

Conclusions

Intravenous L-alanyl L-Glutamine may be an effective measure to lower incidence or prevention of oral mucositis in head and neck cancer patients treated by radiotherapy or combined chemo-radiation.

Clinical trial identification

Legal entity responsible for the study

Tanta University Hospital

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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