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Poster display session

1575 - The efficacy and safety of sorafenib in patients with renal insufficiency of advanced renal cell carcinoma: real- world data of sorafenib in Japan.


10 Sep 2017


Poster display session


Cytotoxic Therapy;  Cancer in Special Situations;  Renal Cell Cancer


Katsunori Tatsugami


Annals of Oncology (2017) 28 (suppl_5): v295-v329. 10.1093/annonc/mdx371


K. Tatsugami1, M. Oya2, K. Kabu3, H. Akaza4

Author affiliations

  • 1 Urology, Graduate School of Medical Science, Kyushu University, 812-8582 - Fukuoka/JP
  • 2 Urology, Keio University School of Medicine, 160-8582 - Tokyo/JP
  • 3 Medical Affairs Oncology And Hematology, Bayer Yakuhin, Ltd., 100-8625 - Tokyo/JP
  • 4 Strategic Investigation On Comprehensive Cancer Network, The University of Tokyo, 153-8904 - Tokyo/JP


Abstract 1575


Multiple treatment options are available for patients with advanced renal cell carcinoma (aRCC). However, the safety/efficacy data of these agents in patients with renal insufficiency are limited. To assess the safety/efficacy of sorafenib in aRCC patients with renal insufficiency, we analyzed the real-world data of a nationwide prospective post-marketing surveillance applying propensity score-matched cohorts.


A total of 3,255 patients with aRCC were enrolled, and 1,226 patients of whom were selected by propensity score matching for estimated glomerular filtration rate (eGFR)


The median PFS in eGFR


Sorafenib has little impact on the renal function in almost all patients with renal insufficiency and provide the fine therapeutic effects for these aRCC patients.

Clinical trial identification

Legal entity responsible for the study

Bayer Yakuhin Ltd.


Bayer Yakuhin Ltd.


K. Tatsugami, M. Oya, H. Akaza: Speaker\'s Bureau: Bayer Yakuhin Ltd., Pfizer, Novartis, Ono Pharmaceutical co., Ltd., and Bristol-Myers. K. Kabu: An employee of Bayer Yakuhin Ltd.

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