Liposarcomas (LPS) are most frequently located in the extremity and recur often, locally as well as on distant sites. There are currently no studies comparing the differences between the different LPS subtypes specifically on this primary site. The aim of this study is to map the differences in recurrence and survival of extremity LPS.
Two retrospective databases (Rotterdam-R, Warsaw-W) of patients treated for primary LPS located in the extremities from 1985-2015 in two tertiary referral centers were used to analyze recurrence patterns (local/distant) and survival.
In total, 456 patients were identified: 192 with well differentiated LPS (WDLPS), 172 myxoid LPS (MLPS), 54 pleomorphic LPS (PLPS), 23 dedifferentiated LPS(DDLPS) and 15 other subtypes (excluded from further analysis). A difference between the two datasets was the frequency of (neo)adjuvant radiotherapy (R: 34.9% vs. W: 81.5%). In the Rotterdam cohort, local recurrence (LR) was observed most frequent in DDLPS (4/13, 5-year LR free survival 56.6%), followed by WDLPS (26/113, 64.9%), PLPS (3/20, 78.6%) and MLPS (10/77, 84.0%, p = 0.136). In the Warsaw cohort, 5-year LR free survival was the lowest in PLPS (9/34, 67.7%), followed by DDLPS (1/10, 83.3%), MLPS (12/95, 84.9%) and WDLPS (3/79, 94.1%, p = 0.001). Distant metastases (DM) were most commonly observed in PLPS in both datasets (5-year DM free survival R: 9/20, 50.3% and W: 16/34, 44.5%), but in the Rotterdam cohort MLPS (16/77, 76.3%) was the second most common subtype with DM, compared to DDLPS (2/10, 62.5%) in Warsaw. DM in WDLPS was rare in both datasets (R:3/113, 96.3%, W: 1/79, 98.5%). 5-year overall survival (OS) did not significantly differ between the two datasets (R: 38/223, 78.5% vs. W: 32/218, 80.9%, p = 0.561), but did significantly differ between the subtypes (R: p = 0.005, W: p
Patients with the four LPS subtypes show distinct patterns of LR, DM and OS. Despite the differences in recurrence, treatment and follow up, OS did not differ significantly between the two expertise centers.
Clinical trial identification
Legal entity responsible for the study
Erasmuc MC Rotterdam
All authors have declared no conflicts of interest.