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Poster display session

5064 - Safety and efficacy of pazopanib (PAZ) in advanced soft tissue carcinoma (aSTS) by prior lines of therapy, age, and dose modifications: PALETTE subgroup analyses


11 Sep 2017


Poster display session


Cytotoxic Therapy;  Soft Tissue Sarcomas


Axel Le Cesne


Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387


A. Le Cesne1, S. Bauer2, G.D.S. Demetri3, W.T.A. van der Graaf4, G. Han5, L. Dezzani5, Q. Ahmad5, H. Gelderblom6

Author affiliations

  • 1 Medical Oncology & Surgery, Gustave Roussy Institut de Cancérologie, 94805 - Villejuif/FR
  • 2 Dept. Of Medical Oncology, University Hospital Essen Westdeutsches Tumorzentrum, 45122 - Essen/DE
  • 3 Center For Sarcoma And Bone Oncology, Dana-Farber Cancer Institute and Ludwig Center, Harvard Medical School, 02215 - Boston/US
  • 4 Sarcoma Unit, The Institute of Cancer Research and the Royal Marsden Hospital , Sutton/GB
  • 5 Novartis Oncology, Novartis Pharmaceuticals, 07936-1080 - East Hanover/US
  • 6 Medical Oncology, Leiden University Medical Center (LUMC), Leiden/NL


Abstract 5064


PALETTE was a randomized phase 3 trial (NCT00753688) that demonstrated single-agent activity of PAZ in advanced STS (aSTS). We evaluated the relationship between age, prior lines of therapy, and dose modifications on the safety and efficacy of PAZ in aSTS.


Median progression-free survival (mPFS) was evaluated in subgroups of prior lines of therapy (1 prior line; 2+ prior lines), age (


A total of 246 patients received pazopanib in the PALETTE study. Median PFS and median overall survival (OS) were longer in patients receiving PAZ who had only 1 prior line of therapy vs 2+ prior lines of therapy (mPFS, 24.7 vs 18.9 weeks [Table]; OS, 13.7 vs 11.3 months). In patients receiving PAZ, mPFS was similar in ages


Longer mPFS was observed in patients receiving PAZ following only 1 line of therapy. Additionally, mPFS with PAZ was maintained regardless of patient age or if dose modification was required to manage toxicity.

Clinical trial identification


Legal entity responsible for the study

Novartis Pharmaceutical Corporation


Novartis Pharmaceutical Corporation


A. Le Cesne: Pharmamar, Lilly, Pfizer, Novartis, Amgen. S. Bauer: Research support: Novartis, Blueprint Medicines, Ariad. Ad board: GSK, Novartis, Pfizer, Bayer, Fresenius, Lilly, Blueprint Medicines, Deciphera. CME-Honoraria: Pharmamar, GSK, Bayer, Novartis. Travel support: Pharmamar, Bayer. G.D.S. Demetri: Grants and personal fees from Novartis, during the conduct of the study; grants and personal fees from Janssen, Eisai, Eli Lilly and PharmaMar, outside the submitted work. W.T.A. van der Graaf: Research grants: GSK, Novartis. Advisory board: Bayer. G. Han, L. Dezzani, Q. Ahmad: Employee of Novartis. H. Gelderblom: Grants to institution LUMC, during the conduct of the study.

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