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Poster display session

1732 - Role of Laparotomy-based Parameters in Assessment of Optimal Primary Debulking Surgery and Long-term Outcomes in Patients with Stage IIIC Epithelial Ovarian Cancer

Date

09 Sep 2017

Session

Poster display session

Topics

Surgical Oncology;  Radiation Oncology;  Ovarian Cancer

Presenters

Mingyi Zhou

Citation

Annals of Oncology (2017) 28 (suppl_5): v330-v354. 10.1093/annonc/mdx372

Authors

M. Zhou, X. Wang, L. Li, C. Wang, D. Wang

Author affiliations

  • Department Of Gynecology, Liaoning Cancer Hospital & Institute, 110042 - Shenyang/CN
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Resources

Abstract 1732

Background

We evaluated the ability of our newly developed laparotomy-based model to predict optimal primary debulking surgery (PDS) and long-term outcomes of stage IIIC epithelial ovarian cancer (EOC).

Methods

Data of 400 IIIC EOC patients who underwent laparotomy were retrospectively analyzed to investigate predictors of optimal PDS. Parameters including infiltration of the bowel, peritoneum, diaphragm, hepatic surface, spleen, and stomach; omental caking; mesenteric retraction; and metastasis of the pelvic and para-aortic lymph nodes increased the difficulty of surgery. The parameters with a specificity ≥75%, positive predictive value ≥50%, and negative predictive value ≥50% were included in the final predictive index value (PIV) model. Each parameter was assigned a score based on the strength of its statistical association, and a total PIV was tabulated for each patient. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive ability of the model. Subgroup analyses were performed in patients with RD > 1 cm and ≤1 cm.

Results

After PDS, 223 (55.8%) patients with RD ≤ 1 cm had longer progression-free survival (PFS) and overall survival (OS) than patients with RD > 1 cm (PFS: 24.3 vs. 15.9 months; P 

Conclusions

When PDS left RD of ≤ 1 cm, patients with a PIV of  1 cm, patients who were sensitive to platinum had a better prognosis. Additionally, patients with a lymph node rate of > 32.5% were more likely to progress.

Clinical trial identification

no

Legal entity responsible for the study

no

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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