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Poster display session

5013 - Risk of malignant mesothelioma in Spain from environmental asbestos exposure

Date

10 Sep 2017

Session

Poster display session

Topics

Cancers in Adolescents and Young Adults (AYA);  Cancer Prevention;  Mesothelioma

Presenters

Junior Smith Torres-Roman

Citation

Annals of Oncology (2017) 28 (suppl_5): v511-v520. 10.1093/annonc/mdx385

Authors

J.S.S. Torres-Roman1, G. Lopez-Abente2, J.M. Sanz-Anquela3

Author affiliations

  • 1 Ica, Faculty of Medicine, Universidad Nacional San Luis Gonzaga, 11702 - Ica/PE
  • 2 Madrid, Cancer and Environmental Epidemiology Unit National Center for Epidemiology Carlos III Institute of Health. Madrid, SPAIN, Madrid - -/ES
  • 3 Madrid, Cancer Registry and Pathology Department Hospital Universitario Principe de Asturias Assoc. Prof. Health Sciences Department of Medicine and Medical Specialties University of Alcalá. Alcala de Henares, Madrid. Spain, -/ES
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Resources

Abstract 5013

Background

The link between malignant mesothelioma (MM), and asbestos exposure (AE), is very high. AE may have occupational or environmental non-occupational source. The highest levels of AE occur in the workplace and mainly affect men. However, environmental AE, affect men and women equally. As the occupational AE prevails over the environmental non-occupational, a sex-ratio < 2 alert of possible environmental AE. The objective of this study is to evaluate the spatio-temporal distribution of the sex-ratio, in order to identify those areas with possibly higher environmental AE.

Methods

We conducted an analysis of the 6,143,124 deaths in Spain during the period 2000–2015, looking for those deaths caused by MM. Information regarding sex, year of death, age at death, province, and cause of death (ICD-10) was extracted from the deceased registry of the National Institute of Statistics. We calculated the sex-ratio between the deceased by MM according to its distribution by provinces and years, and the ratio of mortality rates adjusted for age (European standard population). We also obtained the proportion of MM among the total deceased (MM per 10,000 deaths).

Results

MM deaths were 5,345. Men 4,025 and women 1,329 (sex-ratio: 3.31). During the 2000- 2015 period the sex-ratio remained relatively stable, ranging from 2.21 in 2007 to 4.31 in 2005. In the years 2000 and 2015 the sex-ratio was 3.34 and 3.07, respectively. Likewise, in the years 2000 y 2015 the men/women age-adjusted rates was 2.83 and 3.93, respectively. The variations by provinces were more pronounced. The lowest sex-ratio (1.5) corresponded to the 140 deaths of Navarra and the highest (12.67), to the 41 deaths of Vitoria. Other low sex-ratio values were detected for Almeria (2,07), Donostia (2,02), Huesca (2) and Tarragona (1,97). Among these provinces with a possible higher environmental AE risk (sex-ratio equal to or 

Conclusions

The high provincial variability in Spain of the proportion of women who died of MM, makes necessary the carry out of new research focused in the provinces detected as with a possible greater risk of environmental asbestos exposure in the general population.

Clinical trial identification

Legal entity responsible for the study

Jose Miguel Sanz-Anquela; Junior Smith Torres-Roman

Funding

None

Disclosure

J.M. Sanz-Anquela: Occasionally has served as a consultant to the court, always at the request of plaintiff asbestos victims. All other authors have declared no conflicts of interest.

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