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Poster display session

3140 - Resected malignant melanoma at high risk of recurrence in SEER-Medicare


10 Sep 2017


Poster display session


Cancers in Adolescents and Young Adults (AYA);  Melanoma


Natalia Sadetsky


Annals of Oncology (2017) 28 (suppl_5): v428-v448. 10.1093/annonc/mdx377


N. Sadetsky1, J. Yi2, A. Hernandez1, D. Colburn1, G. Goodman1

Author affiliations

  • 1 Product Development, Genentech, Inc., 94080 - South San Francisco/US
  • 2 Epidemiology/analysis, Genesis Research Group, 07030 - Hoboken/US


Abstract 3140


While surgery remains a mainstay in the management of high-risk resectable malignant melanoma (MM), there is a high chance of recurrence. Utilization of approved adjuvant therapies (e.g. interferon α and ipilimumab) are limited by the common occurrence of debilitating side effects. The objective of our study was to describe characteristics of patients (pts) with resected MM at high risk of recurrence in the older US population.


A retrospective cohort study was undertaken using the Surveillance, Epidemiology, and End Results (SEER)-Medicare population-based linked database. The study population included pts with Stage IIC-IIIC surgically resected MM diagnosed between 2004 and 2011. Demographic and clinical characteristics, adjuvant therapies, including radiation (XRT) and/or systemic therapy (eg, interferon α, interleukin, pegylated interferon), and overall survival (OS) were evaluated.


We identified 1016 pts; the mean age was 75.2 years (interquartile range [IQR], 72–82) and 66.2% were males. The majority of pts had Stage IIC-IIIB disease at diagnosis (Cohort 1; n = 877 [86.3%]); the remainder had stage IIIC disease (Cohort 2; n = 139 [13.7%]). Adjuvant therapy was utilized in 27.3% (n = 239) and 43.2% (n = 60) of pts in Cohorts 1 and 2, respectively, and consisted of XRT in 74% and 78% of pts, systemic therapy in 16% and 10% of pts (with interferon α representing 98.6% of systemic therapies), and a combination of XRT and systemic therapy in 10% and 12% of pts. OS differed between cohorts, with a median of 32.3 months (IQR, 17.9–53.3) for Cohort 1 and 19.8 months (IQR, 11.5–36.2) for Cohort 2. Landmark OS at 5 years was 20.8% for Cohort 1 and 12.2% for Cohort 2.


Among pts with resected MM at high risk of recurrence in the older US population, utilization of adjuvant therapy and OS varied based on disease stage at diagnosis. Pts with Stage IIIC disease were exposed to more medical interventions; however, use of highly toxic systemic therapy available during the study period was limited in both cohorts. As more therapies for the adjuvant setting are being developed, the evaluation of clinical and demographic characteristics may help tailor treatment regimens.

Clinical trial identification

Legal entity responsible for the study

F. Hoffmann-La Roche Ltd.


F. Hoffmann-La Roche Ltd.


N. Sadetsky, A. Hernandez, D. Colburn: Employee, Genentech, Inc. G. Goodman: Employee, Genentech, Inc.; owns stock in Roche. All other authors have declared no conflicts of interest.

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