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Poster display session

2804 - Regulatory variants in cancer-related pathway genes predict survival of patients with surgically resected non-small cell lung cancer

Date

09 Sep 2017

Session

Poster display session

Topics

Cancers in Adolescents and Young Adults (AYA);  Translational Research;  Non-Small Cell Lung Cancer

Presenters

Mi Jeong Hong

Citation

Annals of Oncology (2017) 28 (suppl_5): v453-v456. 10.1093/annonc/mdx381

Authors

M.J. Hong1, K.M. Shin2, S.Y. Lee3, J.H. Lee4, J.Y. Park3

Author affiliations

  • 1 Cell And Matrix Research Institute, Kyungpook National University School of Medicine, 700422 - Daegu/KR
  • 2 Department Of Radiology, Kyungpook National University, Daegu/KR
  • 3 Departments Of Internal Medicine, Kyungpook National University, Daegu/KR
  • 4 Biochemistry And Cell Biology, Kyungpook National University School of Medicine, 700422 - Daegu/KR
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Resources

Abstract 2804

Background

We conducted this study to identify genetic variants in cancer-related pathway genes which can predict prognosis of NSCLC patients after surgery, using a comprehensive list of regulatory single nucleotide polymorphisms (SNPs) prioritized by RegulomeDB.

Methods

A total of 509 potentially functional SNPs in cancer-related pathway genes selected from RegulomeDB were evaluated. These SNPs were analyzed in a discovery set (n = 354), and a replication study was performed in an independent set (n = 772). The association of the SNPs with overall survival (OS) and disease-free survival (DFS) were analyzed.

Results

In the discovery set, 76 SNPs were significantly associated with OS or DFS. Among the 76 SNPs, the association was consistently observed for 5 SNPs (ERCC1 rs2298881C>A, BRCA2 rs3092989G>A, NELFE rs440454C>T, PPP2R4 rs2541164G>A, and LTBP4 rs3786527G>A) in the validation set. In combined analysis, ERCC1 rs2298881C>A, BRCA2 rs3092989, NELFE rs440454C>T, and PPP2R4 rs2541164G>A were significantly associated with OS and DFS (adjusted HR aHR for OS = 1.46, 0.62, 078, and 0.76, respectively; P = 0.003, 0.002, 0.007, and 0.003 respectively; and aHR for DFS = 1.27, 0.69, 0.86, and 0.82, respectively; P = 0.02, 0.002, 0.03, and 0.008, respectively). The LTBP4 rs3786527G>A was significantly associated with better OS (aHR = 0.75; P = 0.003).

Conclusions

Our results suggest that five SNPs in the cancer-related pathway genes may be useful for the prediction of the prognosis in patients with surgically resected NSCLC.

Clinical trial identification

Legal entity responsible for the study

Jae Yong Park

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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