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Poster display session

2300 - Quality of Life (QoL) in Elderly NSCLC Patients (pts) Treated with nab-Paclitaxel/Carboplatin (nab-P/C) in the ABOUND.70+ Trial


09 Sep 2017


Poster display session


Cytotoxic Therapy;  Cancers in Adolescents and Young Adults (AYA);  Geriatric Oncology;  Non-Small Cell Lung Cancer


Corey Langer


Annals of Oncology (2017) 28 (suppl_5): v460-v496. 10.1093/annonc/mdx380


C.J. Langer1, E. Anderson2, R. Jotte3, J. Goldman4, D. Haggstrom5, D. Smith6, C. Dahkil7, K. Konduri8, E. Kim8, A. Sanford9, K. Amiri9, J. Weiss10

Author affiliations

  • 1 Oncology/hematology, Abramson Cancer Center, 19104 - Philadelphia/US
  • 2 Oncology/hematology, Knight Cancer Institute, Portland/US
  • 3 Oncology/hematology, Rocky Mountain Cancer Center, Denver/US
  • 4 Medical Oncology, University of California-Los Angeles, Santa Monica/US
  • 5 Oncology/hematology, Levine Cancer Institute, Charlotte/US
  • 6 Oncology/hematology, Compass Oncology, Vancouver/US
  • 7 Oncology/hematology, Cancer Center of Kansas, Wichita/US
  • 8 Oncology/hematology, Baylor Charles A. Sammons Cancer Center, Dallas/US
  • 9 Oncology/hematology, Celgene Corporation, Summit/US
  • 10 Oncology/hematology, UNC Lineberger Comprehensive Cancer Center, Chapel Hill/US


Abstract 2300


Treatment of elderly pts with advanced NSCLC remains challenging, and the impact of therapies on QoL can be an important factor in clinical decisions. nab-P/C demonstrated efficacy in a subset of pts ≥ 70 yrs with NSCLC in a phase 3 trial. ABOUND.70+ was designed to determine whether a 1-wk break can further improve tolerability of nab-P/C in these patients. QoL outcomes are reported here.


Pts ≥ 70 yrs with locally advanced/metastatic NSCLC were randomized 1:1 to first-line nab-P 100 mg/m2 on d 1, 8, and 15 + C AUC 6 on d 1 of a 21-day cycle (Arm A) or the same regimen with a 1-week break between cycles (Arm B). Primary endpoint: percentage of pts with grade ≥ 2 peripheral neuropathy or grade ≥ 3 myelosuppression. Key secondary endpoints: PFS, ORR, OS for which statistical analyses do not control for type I error (P values unadjusted). QoL (exploratory endpoint) was assessed using Lung Cancer Symptom Scale (LCSS) and EuroQoL-5 Dimensions-5 Levels (EQ-5D-5L) at d 1 of each cycle.


At interim evaluation, primary endpoint was similar across arms, resulting in early closure of enrollment. In Arms A and B, 78% and 79% completed a baseline and ≥ 1 postbaseline QoL assessment. LCSS item of cough improved with each cycle; at the end of cycle 6, mean change from baseline in Arms A and B was 25.4 and 13.8 mm (visual analog scale). For cough, median time to deterioration (TTD) was 4.4 and 4.7 mos (P = 0.7003). For the composite LCSS pulmonary symptom items of cough, shortness of breath, and hemoptysis, the median TTD was 4.4 and 6.0 mos (P = 0.3347). Mean maximum improvement (at any point during treatment) in EQ-5D-5L visual analog scale was 10.1 and 12.8 points. Table lists key safety, efficacy and QoL data.


These results support nab-P/C as a treatment option in elderly pts with NSCLC. Safety (primary endpoint) and OS were similar across the two arms, while there was a signal of improvement in ORR, PFS, and QoL with a 1-wk break. NCT02151149.Table:


Arm A n = 71Arm B n = 72
Primary endpoint, n (%)52/68 (76)54/70 (77)
P value0.9258
Grade ≥ 2 peripheral neuropathy25/68 (37)25/70 (36)
Grade ≥ 3 myelosuppression48/68 (71)45/70 (64)
Neutropenia39/68 (57)39/70 (56)
Anemia14/68 (21)17/70 (24)
Thrombocytopenia17/68 (25)12/70 (17)
Confirmed ORR, %2440
P value0.0376
PFS, median, months3.67.0
P value0.0019
HR (95% CI)0.48 (0.30 - 0.76)
OS, median, months15.216.2
P value0.1966
HR (95% CI)0.72 (0.44 - 1.19)
Mean maximum improvement from baseline, mm
LCSS Total score5.811.7
LCSS Pulmonary symptom9.214.9

Clinical trial identification


Legal entity responsible for the study

Celgene Corporation


Celgene Corporation


C.J. Langer: Consultant/Advisor Role: Celgene. J. Goldman, E. Kim: Research funding: Celgene. K. Konduri: Consultant/Advisory Role: Celgene, Boehringer Ingelheim, DAVA – Pharmaceuticals. A. Sanford, K. Amiri: Employment and stock ownership: Celgene. J. Weiss: Astellas: CME & company sponsored trials (CST); AZ, Biodesix, Clovis, Oncoples: consulting; Celgene: IIT support, CST support, SC; EMD Serono: DSMB member; GSK: IIT support; Medimmune, Pfizer: CST support, IIT support; Merck: CS Tsupport, IIT support. All other authors have declared no conflicts of interest.

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