Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Translational research

2460 - Prominent immune suppressive tumor microenvironment in female never-smoker lung cancer patients with EGFR mutations

Date

09 Sep 2017

Session

Translational research

Topics

Translational Research;  Thoracic Malignancies

Presenters

Byungjo Park

Citation

Annals of Oncology (2017) 28 (suppl_5): v573-v594. 10.1093/annonc/mdx390

Authors

B. Park1, D. Ryu2, H.K. Kim1, J.H. Cho1, J. Lee1, J. Lee3, H. Lee2, J. Joung2, W. Park2, J. Kim1

Author affiliations

  • 1 Thoracic And Cardiovascular Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine, 135-710 - Seoul/KR
  • 2 Molecular Cell Biology, Samsung Genome Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 135-710 - Seoul/KR
  • 3 Biomedical Science, Samsung Biomedical Research Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, 135-710 - Seoul/KR
More

Resources

Abstract 2460

Background

According to genetic and genomic analysis as well as previous clinical research, lung cancer in never-smokers might have pathogenesis and progression different from that of lung cancer among smokers. There has been indirect evidence that different types of mutations in tumors might be related to the altered immune functions.

Methods

Tissues from 110 female patients with lung adenocarcinoma (never-smokers: 102 & smokers: 8) at the Samsung Medical Center, were analyzed by next-generation genomic sequencing including whole-exome seq and RNA-seq. Somatic mutations and gene expression levels of immune signature genes were profiled. The significance for clinical outcome of the selected genes was plotted using Kaplan-Meier method and log-rank test.

Results

Expression biomarkers of immune suppressive cells such as mast cells, macrophage and Treg were prominent in female never-smokers compared to female smokers of lung adenocarcinoma. The data suggest that cells of cytotoxic functions are deactivated in smokers, whereas cells of immune suppressive functions are activated in never-smokers. Specifically as expression of immune markers specific for B-cells, dendritic cells, mast cells and Treg was especially up-regulated (p

Conclusions

This overall immune suppression in lung adenocarcinoma patients with EGFR mutation might explain the lower response rate of anti-PD-1/PD-L1 blockade to the female never smokers, which suggests that other approaches to block the immune suppressive microenvironment would be necessary.

Clinical trial identification

Legal entity responsible for the study

The Institutional Review Board of Samsung Medical Center

Funding

Samsung Cancer Research Institute

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.