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Poster display session

5345 - Prognostic value of NK and T-lymphocyte markers in operable non-small cell lung cancer (NSCLC)

Date

11 Sep 2017

Session

Poster display session

Topics

Translational Research;  Thoracic Malignancies

Presenters

Marcin Skrzypski

Citation

Annals of Oncology (2017) 28 (suppl_5): v595-v604. 10.1093/annonc/mdx391

Authors

M. Skrzypski1, A. Szymanowska-Narloch2, A. Kowalczyk1, A. Maciejewska3, M. Marczyk4, J. Polańska4, W. Biernat5, W. Rzyman6, J. Jassem1

Author affiliations

  • 1 Oncology And Radiotherapy, Medical University of Gdansk, 80-211 - Gdansk/PL
  • 2 Pneumonology And Allergology, Medical University of Gdansk, 80-211 - Gdansk/PL
  • 3 Forensic Medicine, Medical University of Gdansk, 80-211 - Gdansk/PL
  • 4 Data Mining Group, Silesian University of Technology, 44-100 - Gliwice/PL
  • 5 Department Of Pathology, Medical University of Gdansk, Gdansk/PL
  • 6 Thoracic Surgery, Medical University of Gdansk, 80-211 - Gdansk/PL
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Resources

Abstract 5345

Background

New therapies aimed at activation of T and NK cells expand NSCLC treatments options. It is conceivable that markers designating ‘immune ignorant’, ‘immune excluding’ or ‘inflamed’ tumor phenotypes may influence the effectiveness of specific immune therapies.

Methods

qRT-PCR was used to assess the levels of 48 mRNAs in frozen tumor tissue sections from 115 stage I-IIIA NSCLC patients (33% never-smokers, 75% lung adenocarcinoma) who underwent pulmonary resection, and in matched normal lung parenchyma. mRNA expression (normalized vs. 4 reference genes) was compared between groups that did (45%) and did not relapse.

Results

Low expression of TIGIT (p.adj=0.031) and CTLA4 (p.adj=0.048) was correlated with shorter distant metastasis free survival after correction for multiple comparisons. In the subset of 75 lung adenocarcinoma cases, low expression of TIGIT, NCR3, CXCR3, FASLG, CD96, CTLA4, PD1, FYB and FOXP3 was correlated with shorter distant metastasis free survival after correction for multiple comparisons (p.adj

Conclusions

Non-inflamed NSCLC phenotype is associated with higher risk of distant metastases in early stage NSCLC. The non-inflamed phenotype is accompanied by lower expression of chemoattractants for lymphocytes. Expression of immune tolerance markers is increased in NSCLC compared to normal lung tissues.

Clinical trial identification

Legal entity responsible for the study

Medical University of Gdansk

Funding

Medical University of Gdansk

Disclosure

All authors have declared no conflicts of interest.

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