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Poster display session

1103 - Prognostic implication of Inflammation-based Prognostic Scores in Patients with Intrahepatic Cholangiocarcinoma (iCCA) Treated with First-line Gemcitabine Plus Cisplatin (GEMCIS)

Date

09 Sep 2017

Session

Poster display session

Topics

Cytotoxic Therapy;  Hepatobiliary Cancers

Presenters

Hyungwoo Cho

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

H. Cho, C. Yoo, K. Kim, H. Chang, B. Ryoo

Author affiliations

  • Department Of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 138-736 - Seoul/KR
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Resources

Abstract 1103

Background

There is increasing evidence that inflammation-based prognostic scores have prognostic value in several cancer types, including iCCA. However, most of the studies are focused on evaluating their value in patients with resectable disease. We retrospectively evaluated the prognostic implication of inflammation-based prognostic scores including modified Glasgow Prognostic Score (mGPS) based on serum albumin and C-reactive protein, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in patients with unresectable or metastatic iCCA.

Methods

Between April 2010 and May 2015, a total of 296 patients with histologically documented advanced iCCA were treated with first-line GEMCIS in Asan Medical Center, Seoul, Korea. Of these, 257 patients had complete data for inflammation-based prognostic scores and were included in this study. Primary endpoint was overall survival (OS).

Results

Median age was 59 years (range, 27-78) and 158 patients (61.5%) were male. Initially metastatic disease was the most common disease status at GEMCIS (n = 170, 66.1%) followed by recurrence after surgery (n = 44, 17.1%) and locally advanced unresectable disease (n = 43, 16.7%). With a median follow up duration of 25.0 months (95% CI, 19.6-30.4), median OS was 9.1 months (95% CI, 8.0-10.2). In univariate analyses, high mGPS and NLR scores were associated with poorer OS (mGPS 1-2 vs 0: median 6.9 vs 14.1 months, p 

Conclusions

The current study suggests that mGPS might be the relevant prognostic index which can stratify the survival outcomes of patients with unresectable or metastatic iCCA who received first-line GEMCIS.

Clinical trial identification

Legal entity responsible for the study

Asan Medical Center, University of Ulsan College of Medicine.

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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