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Poster display session

1286 - Prognostic Impact of Hepatitis B Virus (HBV) Infection in Advanced Intrahepatic Cholangiocarcinoma (iCCA) Patients (pts) Treated with First-line Gemcitabine Plus Cisplatin (GEMCIS)

Date

09 Sep 2017

Session

Poster display session

Topics

Cytotoxic Therapy;  Hepatobiliary Cancers

Presenters

Eojin Kim

Citation

Annals of Oncology (2017) 28 (suppl_5): v209-v268. 10.1093/annonc/mdx369

Authors

E. Kim, H. Cho, C. Yoo, K. Kim, H. Chang, B. Ryoo

Author affiliations

  • Department Of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 138-736 - Seoul/KR
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Resources

Abstract 1286

Background

HBV infection is a well-known risk factor of iCCA. However, its prognostic impact has rarely been investigated in pts with advanced iCCA who received chemotherapy.

Methods

Between April 2010 and May 2015, a total of 296 pts with histologically documented advanced iCCA received first-line GEMCIS in Asan Medical Center, Seoul, Korea, and were included in this retrospective analysis. Primary endpoint was overall survival (OS). In the multivariate analysis, variables which showed potential association with survival (p 

Results

Median age was 59 years (range, 27-78), and 62 (20.9%) pts with hepatitis B surface antigen positive formed the HBV group. Initially metastatic disease was the most common disease status at the time of GEMCIS (n = 184, 62.2%) followed by recurrence after curative surgery (n = 69, 23.3%) and locally advanced unresectable disease (n = 43, 14.5%). In comparison with the non-HBV group, HBV group were related with young age (mean age 56.4 vs 60.0), male predominance (74.2% vs 57.3%), lower rates of elevated CA 19-9 (42.0% vs 68.5%) and alkaline phosphatase (42.6% vs 60.5%) (p 

Conclusions

Our results suggest that HBV infection might be an independent poor prognostic factor in pts with advanced iCCA treated with first-line GEMCIS. Further translational research is needed to define the differences in the molecular phenotypes between HBV- and non-HBV-associated iCCA.

Clinical trial identification

Legal entity responsible for the study

Asan Medical Center, University of Ulsan College of Medicine

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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