Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Supportive and palliative care

2620 - Prognostic impact of drug interactions in patients with advanced cancer


09 Sep 2017


Supportive and palliative care


Cancers in Adolescents and Young Adults (AYA);  End-of-life Care


Markus Joerger


Annals of Oncology (2017) 28 (suppl_5): v497-v501. 10.1093/annonc/mdx382


M. Joerger1, A. Hömme2, M. Haschke3, S. Krähenbühl3, F. Strasser1, C. Lehner4, A. von Kameke5, T. Wälti6, B. Thürlimann7, M. Früh1, C. Driessen1

Author affiliations

  • 1 Medical Oncology & Hematology, Cantonal Hospital, 9007 - St. Gallen/CH
  • 2 Institute Of Pharmacology & Toxicology, University of Ulm, 89081 - Ulm/DE
  • 3 Clinical Pharmacology & Toxicology, University Hospital Basel and Department of Biomedicine, University of Basel, 4003 - Basel/CH
  • 4 Pharmacy, Cantonal Hospital, 9007 - St. Gallen/CH
  • 5 Information Technology (it), Cantonal Hospital, 9007 - St. Gallen/CH
  • 6 Hci Solutions Inc., HCI Solutions Inc., 3027 - Bern/CH
  • 7 Breast Center, Cantonal Hospital, 9007 - St. Gallen/CH


Abstract 2620


The risk of drug-drug interactions (DDI) increases with the number of comedications. The prognostic impact of DDI in oncology is poorly understood.


We included 105 patients with advanced NSCLC, 100 patients with advanced ER-negative breast cancer (BC) and 100 hospice inpatients (HO) with advanced malignancies between 2010 and 2015. Data collected included all anticancer and non-anticancer drugs received, age, gender, presence of CNS metastases, smoking status, ECOG performance status (PS), Charlson comorbidity score and overall survival (OS) from the time of incurable cancer. Potential DDI were assessed using the hospINDEX of all drugs approved in Switzerland in combination with the DDI software - flycicle mode (HCI Solutions, Bern, Switzerland). Primary study objective was to assess the prognostic value of the severity of DDI per patient cohort using Kaplan-Meier statistics, uni- and multivariate Cox regression models. The study had a power of 84% to detect a survival difference of 25%.


The median number of drugs was 5 (range 0 to 15) in all patients, lowest in BC (4) and highest in HO (6). A major risk for DDI was detected in 74 patients (24.3%) overall, including 29 NSCLC patients (27.6%), 25 BC patients (25.0%) and 20 HO patients (20%). The number of drugs was significantly associated with the risk of DDI (p 


Severity of DDI is a significant and clinically relevant prognostic factor in advanced BC patients. Prospective trials should evaluate the potential benefit of avoiding polypharmacy in this group of patients. In the meantime, increased caution with polypharmacy seems warranted when treating patients with advanced cancer.

Clinical trial identification

2016-00283 (BASEC, national trial identifier)

Legal entity responsible for the study

Markus Joerger MD-PhD ClinPharm




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.