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3007 - Prognosis of desmoid tumours initially managed with surveillance only at all anatomical locations


11 Sep 2017




Cancers in Adolescents and Young Adults (AYA);  Soft Tissue Sarcomas


Winan van Houdt


Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387


W.J. van Houdt1, A.K. Patel1, R.L. Jones2, M.J. Smith1, A. Miah3, C. Benson2, S. Zaidi3, C. Messiou4, E. Moskovic4, D.C. Strauss1, A.J. Hayes1, O. Husson2, W.T.A. van der Graaf2

Author affiliations

  • 1 Surgical Oncology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB
  • 2 Medical Oncology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB
  • 3 Clinical Oncology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB
  • 4 Radiology, Royal Marsden Hospital NHS Foundation Trust, SW3 6JJ - London/GB


Abstract 3007


Desmoid tumours are locally aggressive mesenchymal tumours that lack metastatic potential. Tumour behaviour is unpredictable and varies along a spectrum from remission to growth. Recently, active surveillance has been increasingly adopted as initial management. The aim of this study is to analyse the need and indications for treatment in desmoid patients initially managed with surveillance only.


Patients with a desmoid tumour at any anatomical location diagnosed between 1998 and 2016 were selected from a prospectively maintained database. Differences between patient groups were analysed with independent t-tests or Chi-square tests. Inverse univariate cox proportional hazard regression analyses were conducted to assess factors associated with start of treatment, tumour behaviour and pain.


A total of 168 patients initially managed with surveillance only were identified. The tumours were located in an extremity (51), in the abdominal wall (61), intra-abdominally (15), in the chest wall (30) or at other locations (11). From these patients, 33% (n = 55) developed progressive disease, 38% (n = 64) had stable disease and 28% (n = 47) had a remission. Tumours in patients 5 cm were more likely to undergo treatment (p 


Patients with desmoid tumours can be managed with surveillance only, but a large minority still needs treatment after an initial period of surveillance. Pain and tumour growth are the most common indications to start treatment after initial surveillance.

Clinical trial identification

Legal entity responsible for the study

Winette van der Graaf




All authors have declared no conflicts of interest.

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