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Poster display session

4085 - Postoperative Radiation Therapy After Radical Prostatectomy

Date

10 Sep 2017

Session

Poster display session

Topics

Surgical Oncology;  Radiation Oncology;  Prostate Cancer

Presenters

Asuncion del Carmen Hervas Moron

Citation

Annals of Oncology (2017) 28 (suppl_5): v269-v294. 10.1093/annonc/mdx370

Authors

A.D.C. Hervas Moron, C. Vallejo, J. Domínguez, F. López, M. Martin, D. Candini, E. Carrasco, S. Sancho

Author affiliations

  • Radiation Oncology, Hospital Universitario Ramon y Cajal, 28031 - Madrid/ES
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Resources

Abstract 4085

Background

To analize the results of adjuvant and salvage radiotherapy after radical prostatectomy and to determine prognostic factors of biochemical relapse free survival (BRFS).

Methods

302 patients were treated at our institution over a 12-year period. Overall survival and biochemical-relapse free survival were calculated using Kaplan-Meier and multivariate Cox regression analysis was used to assess differences between groups.

Results

Mean age at diagnosis was 65 years (42-80). All patients underwent radical prostatectomy combined with pelvic lymphadenectomy in 47.1% of cases. Adjuvant RT was performed in 113 patients and salvage RT in 183 (9 for local recurrence). The distribution of patients by pT stage was pT2a-b(30.3%), pT2c (35%), pT3(29%) and pT4(2.3%). Upgrade in Gleason score between biopsy and prostatectomy was experienced by 46.7% of patients. Positive surgical margins were reported in 56.5% of cases. Neoadjuvant androgen ablation before surgery was given to 36.5%. Mean pre-RT PSA of 0.46ng/ml (0-12.8) and mean dosis to surgical bed was of 70Gy (60-76Gy). Mean follow-up was 58.85 months (1-153 months). Overall survival at 5 and 10 years was 98.1% and 94.3%, respectively and BRFS at 5 and 10 years was 76.5% vs. 61.8%, respectively. The timing of RT (ART vs. SRT) and pre-RT PSA

Conclusions

Postoperative radiation therapy provides excellent long-term overall survival with an aceptable BRFS. Pre-RT PSA

Clinical trial identification

Legal entity responsible for the study

Hospital Ramón y Cajal

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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