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Poster display session

3999 - Population sizes of patients (pts) with node negative (N0), HR+, HER2− primary breast cancer (BC), using standard and TAILORx 21-gene Recurrence Score (RS) cut-off values (COV)


11 Sep 2017


Poster display session


Targeted Therapy;  Breast Cancer


Jens-Uwe Blohmer


Annals of Oncology (2017) 28 (suppl_5): v43-v67. 10.1093/annonc/mdx362


J. Blohmer1, M. Verrill2, C. Fortmann3, C. Chao3, J. Gligorov4

Author affiliations

  • 1 Klinik Für Gynäkologie Mit Brustzentrum, Charité-Universitätsmedizin Berlin, 10117 - Berlin/DE
  • 2 Northern Institute For Cancer Research, Newcastle University, Newcastle upon Tyne/GB
  • 3 Medical Affairs, Genomic Health, Inc., Redwood City/US
  • 4 Department Of Medical Oncology, APHP, Hôpital Tenon, Paris/FR


Abstract 3999


Whether to use adjuvant chemotherapy (CT) is a crucial decision for pts with HR+, HER2− primary BC. The 21-gene Recurrence Score® (RS) assay is validated to predict adjuvant CT benefit and risk of recurrence, using standard RS COV of 


Pts with N0, HR+, HER− primary BC and RS results from 2004 to April 2017 were included (data from Genomic Health). Subgroup sizes were determined for RS 


Of 609,247 unique RS records analyzed, 513,035 were from the US, 29,248 from EU countries, and 66,964 from RoW. The relative population sizes of RS subgroups were highly consistent across geographical regions. Deviations in percentages for each RS range were within ±3% (Table). Across all regions, >50% of pts had RS 


Our analysis revealed highly consistent RS subgroup classifications across geographic regions, mirroring observations from registry studies, suggesting that tumor biology as characterized by RS results does not vary by geography. Our findings therefore support the generalizability of outcomes-study results using standard or custom COV across geographic regions.

Clinical trial identification


Legal entity responsible for the study

Jens-Uwe Blohmer


Genomic Health


M. Verrill: Speaker/advisory/research support: Amgen, Genomic Health, Novartis/GSK, Roche. Speaker/advisor: AstraZeneca, Eisai, Teva. Advisor/research support: Pfizer. Advisor: Merck. C. Fortmann, C. Chao: Employment and stock ownership: Genomic Health. J. Gligorov: Advisor: Eisai, Genomic Health, Novartis, Pfizer, Roche. Research support; Eisai, Roche. All other authors have declared no conflicts of interest.

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