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Poster display session

3911 - Pembrolizumab (PEM) in patients with advanced/metastatic bone sarcoma (BS) or soft tissue sarcoma (STS): named patient use by the Medical University of Vienna

Date

11 Sep 2017

Session

Poster display session

Topics

Immunotherapy;  Bone Sarcomas;  Soft Tissue Sarcomas

Presenters

Sophie Schur

Citation

Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387

Authors

S. Schur1, T. Brodowicz1, B. Gad1, R. Hamacher1, G. Amann2, S. Lang2

Author affiliations

  • 1 Clinical Division Of Oncology, Medizinische Universitaet Wien (Medical University of Vienna), 1090 - Vienna/AT
  • 2 Department Of Pathology, Medizinische Universitaet Wien (Medical University of Vienna), 1090 - Vienna/AT
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Resources

Abstract 3911

Background

Treatment options in locally advanced/metastatic BS and STS are limited. PEM has shown first signs of promising activity in some histologic subtypes. In this named patient use BS and STS patients who either failed standard therapy or where no standard therapy was established were treated with PEM.

Methods

This retrospective analysis includes efficacy/safety data from 18 pts. with advanced/metastatic BS/STS treated with PEM 200mg d1, q21d between May 2016 and April 2017.

Results

10 pts. were female (56%), 8 pts. male (44%). Median age was 45 yrs. (range 18-84 yrs.). Extent of disease at initial diagnosis was localized in 15 pts. (83%) and advanced/metastatic in 3 pts. (17%). The median number of previous lines of systemic treatment before PEM was 3 (range 0-7 lines). In total, 71 cycles of PEM were administered (median 3 cycles per pt., range 1-11 cycles). Immune-related side effects were hypothyroidism in two pts. and uveitis in one pt. PD-L1 assessment on tumor samples is ongoing.Table:

1507P

patient IDhistologyn PEM cyclesstatusstatus PEM
1fibromyxoid sarcoma4*1
2OSA1100 NED
3fibrosarcoma3*1
4myxofibrosarcoma800 PR
5myxofibrosarcoma2*1
6angiosarcoma301
7dedifferentiated LPS700 PR
8EMC301
9EMC301
10chondrosarcoma500 SD
11myxoid LPS300 PR
12angiosarcoma1*1
13dedifferentiated LPS500 SD
14synovialsarcoma300 SD
15epitheloid sarcoma300 PR
16OSA200 ie
17OSA300 ie
18myxoid LPS200 ie

Abbreviation: OSA = osteosarcoma, EMC = extraskeletal myxoid chondrosarcoma, LPS = liposarcoma, status 0 = alive, * = dead; status PEM 0 = PEM ongoing, 1 = PEM discontinued to PD (progressive disease); NED = no evidence of disease, PR = partial remission, SD = stable disease, ie = response in evaluation.

Conclusions

In this unselected cohort, PEM seems to have some activity in advanced/metastatic BS/STS. However, longer follow up of treated patients and prospective clinical trials of PEM in BS/STS patients will define the value of PEM in this patient cohort. Updated efficacy and toxicity data as well as PD-L1 expression levels will be presented at the meeting.

Clinical trial identification

Legal entity responsible for the study

Thomas Brodowicz, Clinical Division of Oncology, Medical University of Vienna

Funding

None

Disclosure

S. Schur: Personal fees from Eli Lilly (advisory board) outside the submitted work. T. Brodowicz: Personal fees from Roche and PharmaMar for lecture fees and from Amgen, Bayer, Novartis, Eisai and Eli Lilly for lecture fees and advisory boards. All other authors have declared no conflicts of interest.

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