Systemic treatment outcomes for advanced triple-negative breast cancer (aTNBC) are worse compared to other disease subtypes, due to aggressive behaviour, heterogeneity and lack of molecular targets. Many options are under investigation although most patients receive standard cytotoxic chemotherapy. We aimed to provide better insight into the efficacy of different lines of therapy for aTNBC (overall response rate [ORR], median progression-free survival [mPFS] and median overall survival [mOS]) to better inform discussion with patients, decision-making and referral for clinical trials.
We retrospectively identified 268 patients diagnosed with aTNBC from 01/12/2011 to 30/11/2016 from our electronic records. Patients’ and tumour characteristics were recorded, along with systemic treatment outcomes. Chi-squared/Fishers exact test and Kaplan-Meier statistical methods were utilised.
186 patients treated with ≥1 line of palliative systemic treatment were eligible for the analysis with a median age at 55 (range 26-91). 53.8% had ECOG Performance Status 0 and 69.9% visceral involvement. 38.6% had a disease-free interval (DFI)
The response rates observed in this population of patients are similar to those observed in published clinical trials. However, the PFS rates are short, and as a result early consideration for inclusion in clinical trials of novel approaches can be justified in these patients.
Clinical trial identification
Legal entity responsible for the study
Nicolò Matteo, Luca Battisti
All authors have declared no conflicts of interest.