Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

898 - Oral mucosa dose parameters predicting grade ≥3 acute toxicity in locally advanced nasopharyngeal carcinoma patients treated with concurrent intensity-modulated radiation therapy and chemotherapy

Date

10 Sep 2017

Session

Poster display session

Topics

Cancers in Adolescents and Young Adults (AYA);  Supportive Care and Symptom Management;  Surgical Oncology;  Radiation Oncology;  Head and Neck Cancers

Presenters

Kaixin Li

Citation

Annals of Oncology (2017) 28 (suppl_5): v372-v394. 10.1093/annonc/mdx374

Authors

K. Li1, L. Yang2, Y. Chen3, M. Chen3

Author affiliations

  • 1 Department Of Radiation Oncology, First Hospital of Quanzhou Affiliated to Fujian Medical University, 362000 - Quanzhou/CN
  • 2 Department Of Oncology, Xinyu Peole’s Hospital, 336500 - Xinyu/CN
  • 3 Radiotherapy, Zhejiang Cancer Hospital, 310022 - Hangzhou/CN
More

Resources

Abstract 898

Background

To determine whether volumes based on the contours of the mucosal surface can be used instead of the contours of the oral cavity to predict for grade ≥3 acute oral mucosa toxicity in patients with locally advanced nasopharyngeal carcinoma (LANPC) treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy.

Methods

A standardized method for the oral cavity (oral cavity contours, OCC) and a novel method for the mucosal surface (mucosal surface contours, MSC) were developed for the oral mucosa and prospectively applied to the radiation treatment plans of 92 patients treated with concurrent IMRT and chemotherapy for LANPC. Dose–volume histogram (DVH) data were extracted and analyzed against patient toxicity. Receiver operating characteristic analysis and logistic regression were carried out for both contouring methods.

Results

Grade ≥3 oral mucosa toxicity occurred in 20.7% (19/92) of patients in the study. A highly significant dose–volume relationship between oral mucosa irradiation and acute oral mucosa toxicity was supported by using both oral cavity and mucosal surface contouring techniques. In logistic regression, body weight loss was an independent factor related to grade ≥3 toxicity for OCC and MSC (p=0.017 and 0.005, respectively), and the independent factor of dosimetric parameters for OCC and MSC were V30Gy (p=0.003) and V50Gy (p=0.003), respectively. In the receiver operating characteristics curve, the areas under V30Gy of the OCC curves was 0.753 (p=0.001), and the areas under V50Gy of MSC curves was 0.714 (p=0.004); the cut-off value was 73.155% (sensitivity, 0.842; specificity, 0.671) and 14.32% (sensitivity, 0.842; specificity, 0.575), respectively.

Conclusions

DVH analysis of mucosal surface volumes accurately predicts grade ≥3 oral mucosa toxicity in patients with LANPC receiving concurrent IMRT and chemotherapy, but the MSC method is still no better than the OCC method in clinical application.

Clinical trial identification

NCT02945878

Legal entity responsible for the study

Yuanyuan Chen

Funding

None

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.