Metastatic gastric carcinoma (MGC) patients usually present with cachexia and sarcopenia. We aimed to analyze the prognostic values of the sarcopenia index (SI), cachexia index (CI) and inflammatory indexes (advanced lung cancer inflammation index [ALI], modified Glasgow Prognostic Score [mGPS], prognostic index [PI], prognostic nutritional index [PNI] and neutrophil-to-lymphocyte ratio [NLR]) on MGC at presentation.
A retrospective study was performed in 87 patients with MGC. SI, CI, PI, PNI, ALI, mGPS and NLR was measured and calculated appropriately. Due to lack of studies from our country, SI cutoff value has been obtained by using both western (EGWSOP) and eastern (Harada Y, et al) sources separately. Statistical analysis has been done by SPSS.
Median follow-up time was 9 months (range 1-64) and 78 patients died during follow-up. Fiftynine patients were male (63%) and median age was 62 (23-88). According to univariate analysis these factors had significant negative impact on general survival (GS): increased leukocyte (p = 0,003) and neutrophile (p
On our study; mGPS, PNI and ECOG score were independent indicators for shorter survival. mGPS and PNI, which can be calculated by using only CRP, albumin levels and complete blood counts, might be inexpensive, practical and beneficial in routine clinical practice.
Clinical trial identification
Legal entity responsible for the study
Marmara University Pendik Treatment & Research Hospital, Medical Oncology Department
All authors have declared no conflicts of interest.