If epithelial ovarian cancer (EOC) had a poor prognosis, more than 20% of patients (pts) can expected long remission. Few data are available on long term quality of life (QoL) in these pts and results reported were usually not compared to those of healthy controls. VIVROVAIRE was a large national case-control study comparing pts reported outcomes (PROs) among EOC pts without relapse within 3 years after first line treatment and a group of healthy women.
Pts were recruited in 27 French centers and clinical characteristics were issued from medical charts. Controls were randomized from electoral lists. Pts and controls matched on age. They filled in a form including PROs questionnaires: QoL, neurotoxicity and fatigue (FACT/G, FACT/O, FACT/GOG-Ntx, FACT/F), anxiety and depression (HADS), sleep disturbance (ISI) and Physical activity (IPAQ).
318 pairs were analysed (from 349 pts and 327 controls included). Median age: 65 (20-86), high level of education: 52% and 58%, respectively. Pts characteristics: FIGO stage I/II (49%), III/IV (47%) unknown (4%); major histology, serous (50%), endometrioid (16%), clear cells (8%), mucinous (4%). BRCA1/2 mutations (n = 21; 15%), unknown (n = 168). 99% of the pts had a surgery and 96% received platinum based chemotherapy, associated with antiangiogenic agent (14%) Interval from first line therapy: median 5 years [2 to 24]. Pts reported lower physical and functioning QoL scores (p = 0.03 and p = 0.0002), higher score of fatigue (p
Compared to healthy women, EOC pts presented poorer long term QoL, fatigue with important neurotoxicity and digestive symptoms. Physicians have to take in count of the late effects of treatments to help the pts to cope with the sequelae.
Clinical trial identification
Not applicable (Observational study)
Study approved by CCTIRS and CNIL
Legal entity responsible for the study
Centre François Baclesse
Fondation de France; Ligue Nationale Contre le Cancer
All authors have declared no conflicts of interest.