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Poster display session

5466 - Levetiracetam offers a survival advantage in patients with epilepsy related to MGMT-unmethylated Glioblastoma

Date

10 Sep 2017

Session

Poster display session

Topics

Central Nervous System Malignancies

Presenters

Leonardo Rojas

Citation

Annals of Oncology (2017) 28 (suppl_5): v109-v121. 10.1093/annonc/mdx366

Authors

L. Rojas1, A. Ruiz-Patiño2, A.F. Cardona3, O. Arrieta4, Z. Zatarain-Barrón4

Author affiliations

  • 1 School Of Medicine, Pontificia Universidad Javeriana, 220246 - Bogotá/CO
  • 2 School Of Medicine, Hospital Universitario San Ignacio-Pontificia Universidad Javeriana, 110231 - Bogotá/CO
  • 3 Clinical Oncology, Foundation for Clinical and Applied Cancer Research FICMAC, Bogotá/CO
  • 4 Thoracic Oncology Unit And Laboratory Of Personalized Medicine, Instituto Nacional de Cancerologia - Mexico, 14080 - Ciudad de México/MX
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Resources

Abstract 5466

Background

Epilepsy is a common symptom in patients with glioblastoma (Gb). Levetiracetam (LEV), an antiepileptic drug (AED), enhances MGMT inhibition and reduces chemotherapy mediated neuronal toxicity, offering a theoretical benefit over other AEDs.

Methods

213 Hispanic patients were included. All patients underwent surgery (if feasible) followed by chemoradiation based on temozolomide. Type of AED was selected under treating physician discretion. Recorded variables included demographics, AED, dosage, MGMT status, performance status (PS) and type of surgical intervention. The relationship between overall survival (OS), AED and MGMT methylation status was explored.

Results

Mean age was 53-yo (SD+/-14.7), 56.8% were male, 73% presented with epilepsy after diagnosis and 50.7% harbored methylated MGMT (metMGMT). 41% were treated with LEV, 26% were given another AED and 33% did not require any AED. AED indication was not associated with age (p = 0.087), PS (p = 0.78) anatomic tumor site (p = 0.34) or MGMT status (p = 0.98). Median OS was 25.8 months (95%CI 21.6-31.5), 27.9 months (95%CI 23.8-33.7) for those with metMGMT, and 11.83 months (95%CI 7.73-16.67) for non-metMGMT (p 

Conclusions

Retrospective analysis of this cohort suggests that LEV modifies OS in non-metMGMT Gb patients making it comparable to those with metMGMT. Further validation of this data in clinical trials is warranted.

Clinical trial identification

Legal entity responsible for the study

Leonardo Rojas

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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