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Poster display session

3173 - Incidence and survival of secondary malignances (SM) in oropharingeal squamous cell carcinoma (OPSCC): a homogeneous single report institution


10 Sep 2017


Poster display session


Cancers in Adolescents and Young Adults (AYA);  Head and Neck Cancers


Martina Napolitano


Annals of Oncology (2017) 28 (suppl_5): v372-v394. 10.1093/annonc/mdx374


M. Napolitano1, F. Bertolini1, E. D'Angelo2, A. Spallanzani1, S. Tassi3, B. Meduri2, S. Bettelli4, R. Depenni1, A. Ghidini3, F. Lohr2, L. Presutti3, S. Cascinu1

Author affiliations

  • 1 Department Of Oncology, Modena University Hospital, 41124 - Modena/IT
  • 2 Radiotherapy Service, Modena University Hospital, Modena/IT
  • 3 Ent Surgery Dept, Modena University Hospital, Modena/IT
  • 4 Molecular Biology Lab, Modena University Hospital, Modena/IT


Abstract 3173


SM in HNSCC patients (pts) are common, due to the presence of risk factors (smoking habit or alcohol abuse). Aim of this report is to evaluate the incidence and characteristics of SM in a series of OPSCC.


We retrospectively reviewed clinical data of 266 pts with OPSCC seen at Modena University Hospital between 2006 and 2016. We recorded data from a web platform in which every pt has a personal form filled with clinical information. In particular, we analyzed the rate of SM and described clinical and survival data.


SM was diagnosed in 37 pts (13,9%): 15 NSCLC (5% on all; 40,5% of SM); 7 HNSCC (18,9%), 8 GI (21,6%), 2 prostate (5,4%), 2 thyroid cancer (5,4%), 2 hematologic malignancy (5,4%) and 1 melanoma (2,7%). Clinical features at diagnosis for OPSCC: 30 (81%) male, 7 (19%) female; median age 68 years (range 37-90). Twenty-five pts (67,6%) were current/former smokers, 26 (70,3%) HPV-positive; stage at diagnosis was I-II in 5 (13,5%) and III-IV in 32 pts (86,5%). Eleven pts developed SM 


In our retrospective series, we confirmed that secondary lung cancer was the most frequent SM; it was diagnosed at earlier stage, because these pts underwent a periodical follow-up for their previous OPSCC with a chest X-ray/CT. Smokers may benefit from a more intensive follow-up for a higher risk of smoking related SM (lung, HNSCC). Survival is more influenced by the occurrence of SM than by OPSCC. All these considerations should be applied to a larger series.

Clinical trial identification

Legal entity responsible for the study

Modena University Hospital




All authors have declared no conflicts of interest.

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