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Sarcoma

1261 - Improved overall and progression free survival after surgery in expert sites for sarcoma patients: a nationwide study of FSG-GETO/NETSARC

Date

09 Sep 2017

Session

Sarcoma

Topics

Cancers in Adolescents and Young Adults (AYA);  Sarcoma

Presenters

Jean-Yves Blay

Citation

Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387

Authors

J. Blay1, E. Stoeckle2, A. Italiano3, R.A. Rochwerger4, F. Duffaud5, S. Bonvalot6, C. Honore7, G. Decanter8, C. Maynou9, P. Anract10, G. Ferron11, F. Guillemin12, F. Gouin13, M. Rios14, J.E. Kurtz15, P. Meeus16, J.M. Coindre17, I. Ray-Coquard1, N. Penel18, A. Le Cesne19

Author affiliations

  • 1 Medicine, Centre Léon Bérard, 69008 - Lyon/FR
  • 2 Surgery, Institute Bergonié, 33076 - Bordeaux/FR
  • 3 Medicine, Institute Bergonié, 33076 - Bordeaux/FR
  • 4 Surgery, Hopital Tmone, 13000 - Marseille/FR
  • 5 Oncology, CHU La Timone Adultes, 13385 - Marseille/FR
  • 6 Surgery, Curie, 75005 - Paris/FR
  • 7 Surgery, Institut Gustave Roussy, 94805 - Villejuif/FR
  • 8 Surgery, Centre Oscar Lambret, 59000 - Lille/FR
  • 9 Surgery, CHRU Lille, 59000 - Lille/FR
  • 10 Surgery, CHU Cochin, 75014 - Paris/FR
  • 11 Surgery, Centre Claudius-Regaud, 31052 - Toulouse/FR
  • 12 Surgery, Institut Jean Godinot, 51100 - Reims/FR
  • 13 Surgery/orthopedy, CHU Nantes, 44000 - Nantes/FR
  • 14 Med, Institut de Cancérologie de Lorraine - Alexis Vautrin, 54519 - Vandoeuvre les Nancy/FR
  • 15 Oncology, CHU Hautepierre, 67200 - Strasbourg/FR
  • 16 Chirurgie, Centre Léon Bérard, 69008 - Lyon/FR
  • 17 Pathology, Institute Bergonié, 33076 - Bordeaux/FR
  • 18 Medicine, Centre Oscar Lambret, 59020 - Lille/FR
  • 19 Medical Oncology & Surgery, Gustave Roussy Institut de Cancérologie, 94805 - Villejuif/FR
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Resources

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Abstract 1261

Background

Sarcomas are rare but aggressive diseases. Specialized multidisciplinary management is not implemented for all patients in most countries. We investigated the impact of the surgery in a reference center on relapse and survival in the nationwide NETSARC/RREPS study.

Methods

NETSARC (netsarc.org) is a network of 26 reference sarcoma centers with specialized MDTB, funded by the French National Cancer Institute to improve the outcome of sarcoma patients. Since 2010, presentation to an MDTB and second pathological review are mandatory for sarcoma patients. Patients’ characteristics and follow-up are collected in a database regularly monitored. Uni and multivariate analysis of prognostic factors for local relapse free survival (LRFS), relapse free survival (RFS) and overall (OS) were conducted.

Results

Out of the 9,594 non-metastatic pts aged > =15, with a first diagnosis of soft tissue and visceral sarcoma obtained between Jan 2010 and Dec 2014, 3505 (37%) and 6089 (63%) were operated within vs outside of one of the 26 NETSARC reference center. The former group had worse prognostic characteristics (age, size, grade, depth p 

Conclusions

In this nationwide unselected population, the LRFS and RFS of sarcoma patients is worse than that reported in expert centers series. Surgery in reference center is associated with significant reduction of the risk of relapse and death.

Clinical trial identification

This is not a clinical trial this is a registry of sarcoma approved by the French NCI and competent authorities in France (CNIL)

Legal entity responsible for the study

NetSARC/French Sarcoma Group_GETO

Funding

INCA DGOS

Disclosure

All authors have declared no conflicts of interest.

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