Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

3679 - Immune expression profile and sunitinib benefit in metastatic clear cell renal cell carcinoma (ccRCC)


10 Sep 2017


Poster display session


Cytotoxic Therapy;  Renal Cell Cancer


Oscar Reig Torras


Annals of Oncology (2017) 28 (suppl_5): v295-v329. 10.1093/annonc/mdx371


O. Reig Torras1, M. Marín_aguilera1, N. Jimenez1, L. Paré1, P. Galvan1, C. Mallofre2, A. Prat1, B. Mellado Gonzalez1

Author affiliations

  • 1 Medical Oncology, Hospital Clinic y Provincial de Barcelona, 8036 - Barcelona/ES
  • 2 Pathology, Hospital Clinic y Provincial de Barcelona, 8036 - Barcelona/ES


Abstract 3679


The identification of predictive biomarkers may be useful to select antiangiogenic or immunotherapy treatment in renal cell carcinoma. We here investigated the immune expression profile in sunitinib (SU) or anti-PD1/PD-L1 treated ccRCC patients.


Forty-two metastatic ccRCC patients treated with SU and 10 patients treated with anti-PD1/PD-L1 antibodies were included in this retrospective biomarker study. 730 immune-related genes (nCounter® PanCancer Immune Profiling Panel, Nanostring) were tested in FFPE tumor specimens. Different immune gene signatures were correlated with clinical outcome. A differential expression analysis between refractory (progression-free survival (PFS) < 3 months) and sensitive (PFS > 3 months) patients to SU and anti-PD1/PD-L1 therapies was performed.


Patients who achieved a partial or complete (P/CR) response with SU had a higher score of B cell, CD8 T cell, T cell, Th1 cell, Th2 cell, Treg cell and Stromal signatures. Moreover, these signatures were predictive of P/CR to sunitinib (p-value for odds ratio < 0.05). T cell signatures (CD8 T cell, T cell, Th1 cell, Th2 cell and Treg cell) were correlated with a better PFS, while activated dendritic cell (aDC) and stromal signatures were correlated with a better OS (Table). In the cohort of anti-PD-1/PD-L1 treated patients, no differences in the immune signatures were found between responders and no-responders to these drugs. However, differential expression analysis revealed a single gene, TIM-3, that was associated with resistance to anti-PD1/PD-L1 therapies and benefit to SU in ccRCC patients.Table:


SignaturesProgression-Free SurvivalOverall Survival
HR (95% CI)PHR (95% CI)P
CD8Tcell0.57 (0.37 – 0.89)0.012350.64 (0.39 – 1.03)0.0684
Th1cell0.62 (0.41 – 0.95)0.028410.70 (0.43 – 1.14)0.1491
Tcell0.68 (0.48 – 0.98)0.039510.79 (0.52 – 1.19)0.2649
Tregcell0.67 (0.45 – 0.98)0.041260.76 (0.49 – 1.18)0.2146
Th2cell0.48 (0.24 – 0.97)0.041550.62 (0.30 – 1.26)0.1853
Stromal0.72 (0.50 – 1.03)0.069230.64 (0.43 – 0.96)0.0291
Bcell0.69 (0.47 – 1.03)0.072710.74 (0.48 – 1.14)0.1698
aDC0.78 (0.46 – 1.34)0.371360.53 (0.29 – 0.95)0.0330
iDC0.91 (0.52 – 1.58)0.740050.69 (0.37 – 1.32)0.2649


T cell signatures may be associated with benefit to SU in ccRCC. The value of TIM-3 as a potential biomarker in ccRCC merits further exploration.

Clinical trial identification

Legal entity responsible for the study

Hospital Clínic de Barcelona


Fundació Clínic per a la Recerca Biomèdica


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.