Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

1883 - Efficacy of recombinant human endostatin combined with chemotherapy in advanced pancreatic neuroendocrine tumors

Date

10 Sep 2017

Session

Poster display session

Topics

Cytotoxic Therapy;  Neuroendocrine Tumours

Presenters

Yuejuan Cheng

Citation

Annals of Oncology (2017) 28 (suppl_5): v142-v157. 10.1093/annonc/mdx368

Authors

Y. Cheng

Author affiliations

  • Medical Oncology, Peking Union Medical College Hospital, 100730 - Beijing/CN
More

Resources

Abstract 1883

Background

Dacarbazine or temozolomide, an oral analog of dacarbazine, showed activity against advanced pancreatic NETs when administered alone or in combination with other agents. Targeting pathways involved in angiogenesis, such as VEGFR TKI is also active in advanced pNETs. Endostatin is an endogenous angiogenesis inhibitor, rhEndostatin combined with chemotherapy prolonged overall survival compared with chemotherapy alone in advanced non-small cell lung cancer.

Methods

14 patients with histologically confirmed, locally advanced or metastatic pancreatic well-differentiated NETs with radiologic progression within the previous 12 months received the study regimen: Temozolomide was administered orally 150-200 mg/m2/d, d1-7. Dacarbazine and 5-FU were both administered intravenously at a dose of 250mg/m2/d and 500mg/m2/d respectively, d1-5. rhEndostatin was administered intravenously at a dose of 15mg/d, d1-14, repeated every 21 days. CT/MRI was performed at baseline and every 3 cycles after initiation of treatment. Radiologic response was classified according to RECIST 1.1 criteria.

Results

Patients received a median of 6 treatment cycles (range, 2 to 8 cycles). Of the 14 patients, 6 patients received temozolomide and 8 received the DTIC + 5-FU combined with rhEndostatin. 5 patients used temozolomide as maintenance therapy, the median maintenance therapy cycles was 6 (range, 2 to 18 cycles). ORR was 43% (CR: 1 patient, PR: 5 patient), DCR was 86%, mPFS was 12 months, overall survival has not been reached. No grade 3/4 toxicity occurred.

Conclusions

rhEndostatin combined with temozolomide or darcarbazine-based chemotherapy was effective in treatment of advanced pNETs and was well tolerated.

Clinical trial identification

NCT01845675

Legal entity responsible for the study

Peking Union Medical College Hospital, Ethic Committee

Funding

None

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.