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Poster display session

5502 - Efficacy of panitumumab and cetuximab in elderly patients (aged ≥75) with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (mCRC): retrospective analysis of data from nationwide Drug-Reimbursement-Access Program

Date

09 Sep 2017

Session

Poster display session

Topics

Cytotoxic Therapy;  Geriatric Oncology;  Colon and Rectal Cancer

Presenters

Marcin Swierkowski

Citation

Annals of Oncology (2017) 28 (suppl_5): v158-v208. 10.1093/annonc/mdx393

Authors

M. Swierkowski1, A. Ptak-Chmielewska2, A. Sliwczynski3, T. Czeleko3, Z. Teter3, C. Szczylik4

Author affiliations

  • 1 Department Of Oncology, Military Insitute of Medicine, 04-141 - Warsaw/PL
  • 2 Institute Of Statistics And Demography, Warsaw School of Economics, Warsaw/PL
  • 3 Warsaw, National Health Fund, Warsaw/PL
  • 4 Department Of Oncology, Military Insitute of Medicine, Warsaw/PL
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Resources

Abstract 5502

Background

Panitumumab and cetuximab are standards of treatment for chemotherapy-refractory, wild-type KRAS exon 2 mCRC patients. There are limited data on efficacy of these drugs in elderly patients.

Methods

Data were obtained from 2425 patients enrolled into nationwide Panitumumab/Cetuximab Reimbursement-Access Program ongoing in 62 Polish cancer centres. All reported patients were included to analyses from April 2012 to December 2015. Key inclusion criteria to the program: mCRC, refractory to chemotherapy (5FU, oxaliplatin, irinotecan), aged ≥18 years, wild-type KRAS exon 2 tumour status, measurable disease, ECOG performance status 0-2. Inclusion and exclusion criteria were the same for panitumumab and cetuximab therapy in all centres. Pre-planned, uniform schedule of efficacy assessment (every 12 weeks) was applied from start of therapy in all centres. Individual patients data concerning efficacy outcome measures were entered prospectively via electronic system into databases of public, national payer - National Health Fund (NFZ). We performed retrospective analysis using Kaplan-Meier method to assess overall survival (OS) and progression-free survival (PFS). OS and PFS were compared by log-rank test between patients aged

Results

Out of 2425 patients, 247 were aged ≥75 years (10%) (165 patients received panitumumab and 82 received cetuximab). In panitumumab group, median OS was comparable in younger and older patients, 9.9 vs 9.6 months, respectively (HR, 1.07; 95% CI: 0.87-1.31; p = 0.5121), as was median PFS, 5.5 vs 5.8 months (HR, 1.08; 95% CI: 0.85-1.38; p = 0.5206) (n = 994 vs n = 130). In cetuximab group, median OS was also comparable in younger and older patients, 10.2 vs 9.9 months, respectively (HR, 0.95; 95% CI: 0.73-1.23; p = 0.6749), as was median PFS, 5.2 vs 5.2 months (HR, 0.92; 95% CI: 0.67-1.30; p = 0.6352) (n = 559 vs n = 60).

Conclusions

Panitumumab and Cetuximab provide similar efficacy outcomes in younger and older patients in everyday practice.

Clinical trial identification

Legal entity responsible for the study

Military Institute of Medicine, Warsaw National Health Fund, Poland

Funding

None

Disclosure

M. Swierkowski: Consulting role with Pfizer. C. Szczylik: Consulting role with Pfizer, Bayer, Ipsen. All other authors have declared no conflicts of interest.

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