The local delivery of drug into brain has not been widely used because the unpredictable dose distribution and dose-toxicity effects that drug may carry. This study is to investigate the efficacy of drug delivery by intra-cerebral injection.
3 patients with deep-seated glioma underwent stereotactic biopsy and Ommaya reservoir implantation. Radioactive agent (131I-chTNT) was injected at a dose of (0.8mCi/cm3) through Ommaya reservoir. Patients were carefully observed and Post-operational PET was performed to reveal the body distribution of 131I and evaluate the distribution of drugs in whole body.
After the intratumoral injection, most of the drug stayed in the brain tumor and decayed gradually for more than 4 weeks. Although the accumulation of 131I was also found in thyroid and urinary system as well as stomach and large intestine, it disappeared within 2 weeks while strong radioactivity was still seen in the brain tumor.
These images demonstrated excellent localization of the radiolabel in the tumor with little diffusion over time. Intra-tumoral injection of chemical or readioactive drugs is recommendable in the local treatment.
Clinical trial identification
Legal entity responsible for the study
Beijing Capital Developmental Fund (2014-2-5021)
All authors have declared no conflicts of interest.