Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

5226 - Does hyper-progression exist among head and neck cancer patients treated with immunotherapy?


10 Sep 2017


Poster display session


Cancers in Adolescents and Young Adults (AYA);  Immunotherapy;  Head and Neck Cancers


Ana Ortega Franco


Annals of Oncology (2017) 28 (suppl_5): v372-v394. 10.1093/annonc/mdx374


A. Ortega Franco1, M. Plana1, I. Braña2, M. Taberna Sanz3, M. Oliva Bernal1, S. Vázquez1, M. Domenech Vinyolas4, G. Berenguer1, E. Vilajosana1, M. Bergamino1, N. Baste5, R. Mesia Nin6

Author affiliations

  • 1 Medical Oncology, Institut Catala de Oncologia, 8907 - Barcelona/ES
  • 2 Molecular Therapeutics Research Unit, Vall d'Hebron Institute of Oncology, 08015 - Barcelona/ES
  • 3 Medical Oncology, Institut Català d'Oncologia Hospital Duran i Reynals, 8907 - Barcelona/ES
  • 4 Clinical Oncology, Institut Catala de Oncologia, 8907 - Barcelona/ES
  • 5 Medical Oncology, Vall d'Hebron Institute of Oncology, 08015 - Barcelona/ES
  • 6 Medical Oncology, Institut Català d'Oncologia Hospital Duran i Reynals, 08907 - Barcelona/ES


Abstract 5226


Immunotherapy (IM) improves survival (OS) in recurrent/metastatic squamous cell carcinoma of the head and neck (HNSCC) patients after platinum progression. Hyper-progression (HP) is a pattern of accelerated tumor growth with ECOG deterioration (ECOGdt) that has been described in patients (p) with solid tumors within the first weeks of IM.


HP is defined by twofold increase in tumor growth rate (TGR) (1). Our aim was to detect HP in a cohort of HNSCC p treated with IM in clinical trials in 2 cancer centers (ICO, VHIO). 1 S Champiat. Clin Cancer Res, 2016.


From 08/2014 to Dec/2016, 69p were included in IM trials. Among them, 46p were evaluable for TGR. Baseline characteristics and IM are listed in Table. After a median follow-up of 9.4 months (m) (1-27), 36p have progressed and 24 have died. Median overall survival (mOS): 14m (8-20), percentile 75% 5m (3-7). TGR decreased in 33 p. TGR increased in 13p, presenting two-fold TGR in 2p, with 2 IM discontinuation within 2 months and 1 ECOGdt, with no differences in mOS compare to the rest (p = 0.8). We also identify 9p with progression within 2m and rapid ECOGdt, which were defined as early progressors (EP). A comparative analysis between EP and no EP was performed (Table). Within EP p, there is a lower proportion of objective response (OR), PDL-1 positivity and cisplatin sensitive (CS) tumors (p > 0.1). EP p had significantly higher proportion of tumor complications (p = 0.013) and worse mOS: 3m (0.8-5.9) vs 15m (3.9-26), HR 3.9 (1.2-10) p 0.008.Table:


All cohort n = 46 n (%)Progression n = 36
No EP n = 27EP n = 9p value
Male39 (85)2281
Smokers42 (91)2490.6
PDL-1 n = 33 Positive Negative21 (45) 22 (48)14 112 60.2
Locoregional disease (LRD) Metastatic without LRD33 (71) 13 (29)22 55 40.2
Previos systemic therapy 0 1 2 ≥33 (7) 11 (24) 30 (65) 2 (4)1 5 20 10 2 6 10.5 1 0.7 0.4
OR (n = 44)11 (25)700.1
TGR increase13 (28)920.7
CS (n = 40)23 (58)1740.4
AntiPD-1 AntiPDL-1 AntiPDL-1 + CTLA-4 Immunomodulator (IMD) AntiPDL-1 + IMD AntiPD-1 + CT9 (20) 11 (24) 16 (35) 4 (9) 2 (3) 4 (9)5 8 7 4 1 22 1 5 0 1 00.6 0.5 0.1 0.5 0.4 1
Tumor complications8 (17)350.013


In our cohort, we did not detect HP as previously defined. However, there is a proportion of p that has poor survival due natural HNSCC history, these p lack of benefit from IM monotherapy and other strategies should be explored.

Clinical trial identification

Legal entity responsible for the study

Catalan Institute of Oncology




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.