Pazopanib has been approved for first-line treatment of patients (pts) with mRCC based on the prospective randomized trial that enrolled only pts with adequate renal function. There are no data on the efficacy and toxicity of pazopanib in pts with renal insufficiency (RI). The aim of this study is to investigate the effect of kidney function on treatment outcomes in pts treated with pazopanib for mRCC.
We retrospectively analyzed the data of the mRCC pts treated with pazopanib with respect to renal function in fourteen Italian institutions from January 2010 to June 2016. Baseline glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease (MDRD) formula at the time of therapy initiation. Pts with MDRD
Two hundred and twenty-nine pts with mRCC were included in this study: 128 pts in group A and 101 pts in group B. 68% of pts were male, median age was 67 years (34-88) and median CrCl was 49,7 ml/min in group A. In group B, 64% of pts were male, median age was 64 years (38-85) and median CrCl was 74 ml/min. Pts with MDRD
Although in this study it is necessary to reduce the dose of pazopanib more frequent in pts with RI, kidney function at therapy initiation does not adversely affect the efficacy and safety of pazopanib.
Clinical trial identification
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All authors have declared no conflicts of interest.