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Poster display session

5252 - Clinical impact of atypical phenotypes in adult t cell lymphoma/leukemia among HTLV carriers

Date

09 Sep 2017

Session

Poster display session

Topics

Cancers in Adolescents and Young Adults (AYA);  Leukaemia;  Lymphomas

Presenters

Daniel Enriquez Vera

Citation

Annals of Oncology (2017) 28 (suppl_5): v355-v371. 10.1093/annonc/mdx373

Authors

D. Enriquez Vera1, G. De la Cruz Ku2, J. Haro Varas3, P. Rioja1, Z. Morante Cruz3, N.I. Valdiviezo Lama1, R. Luque2, E. Eyzaguirre2, M. Lujan2, A. Saavedra2, M. Mayuri Monsefu1, G. Ferreyros1, M. Retamozo Alvarado1, J. Vidal Ayllón1, S. Neciosup Delgado1, L.A. Mas Lopez1

Author affiliations

  • 1 Medical Oncology, Instituto Nacional de Enfermedades Neoplasicas - INEN, Lima 34 - Lima/PE
  • 2 Student, Universidad Cientifica del Sur, 15086 - Lima/PE
  • 3 Medical Oncology, INEN, 15 - Lima/PE
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Resources

Abstract 5252

Background

ATLL represents a fatal disease epidemiologically linked to chronic infection with human T-cell lymphotropic virus type 1 (HTLV1). The diagnosis is classically described based on morphology, immunophenotype (typically CD7, CD8, CD56, ALK, EBV and PAX5 negatives). Our aim was to describe characteristics and compare outcomes between patients with classical ATLL and those with mature T-cell lymphoma and HTLV1 infection (atypical ATLL).

Methods

We reviewed 276 medical records from pts with HTLV1 infection and T-cell lymphomas diagnosed between 2008-2014 at the Instituto Nacional de Enfermedades Neoplasicas (Peru). Groups were divided based on presence of classical characteristics of ATLL, outcomes and survival differences were calculated by log-rank test in the univariate analysis and Cox regression analysis for prognostic factors.

Results

From 276 pts, 126 (45%) had classical ATLL phenotype and 150 (54%) were atypical. Mean age was 56 years and 19% were

Conclusions

It seems that there are atypical presentations of adult T cell lymphoma/leukemia with slightly better response to chemotherapy and survival, further studies with integration of viral RNA to neoplastic tissues are needed to confirm this category.

Clinical trial identification

Legal entity responsible for the study

Instituto Nacional de Enfermedades Neoplasicas

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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