Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

2178 - Characteristics and prognosis of gastrointestinal stromal tumor in the pre-imatinib era: an analysis based on the Kinki GIST registry in Japan


11 Sep 2017


Poster display session




Tadayoshi Hashimoto


Annals of Oncology (2017) 28 (suppl_5): v521-v538. 10.1093/annonc/mdx387


T. Hashimoto1, T. Takahashi2, Y. Kurokawa1, J. Fujita3, S. Hirota4, T. Nishida5, T. Tsujinaka6

Author affiliations

  • 1 Department Of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 565-0871 - Suita/JP
  • 2 Department Of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita/JP
  • 3 Department Of Surgery, Sakai Medical Center, 593-8304 - Sakai/JP
  • 4 Surgical Pathology, Hyogo College of Medicine, 663-8501 - Nishinomiya/JP
  • 5 Director, National Cancer Center Hospital, 104-0045 - Tokyo/JP
  • 6 Department Of Surgery, Kaizuka City Hospital, 597-0015 - Kaizuka/JP


Abstract 2178


Recent breakthroughs regarding the oncogenesis of gastrointestinal stromal tumor (GIST) have led to the wider use of imatinib (IM). In addition, since perioperative IM has been established, more accurate information regarding the clinical behavior of GIST is mandatory. However, there is no big data about the clinicopathological characteristics and prognosis of GIST in Japan. The aim of this study was to clarify them based on an analysis of the GIST registry conducted by the Kinki GIST Study Group in Japan.


The registry was designed to collect data on background characteristics, treatment methods, pathologic characteristics, and prognosis of primary GIST from 2003 through 2007 at 40 participating institutions.


The study enrolled 346 male patients and 332 female patients. The median [range] age was 66 [18-93] years. The primary sites were stomach (74%), small intestine (19%), rectum (3%), esophagus (1%), colon (1%), and others (1%). Fifty-eight percent were asymptomatic and 42% were symptomatic e.g. bleeding (17%), pain (10%), and digestive symptoms (9%). None of the patients was received perioperative IM therapy. Pathological examination revealed that the tumor size was 4.0 [0.1-35]cm and the mitotic count was 3 [0-300] per 50 high-powered fields. There were 91.0% KIT positive GISTs and 82.9% CD34 positive GISTs. Ninety-seven (14.5%) patients showed recurrence and the common recurrent sites were liver (n = 58) and peritoneum (n = 33). According to the modified-Fletcher criteria, the recurrence rates were 0% (0/93, very low-risk group), 2.6% (6/230, low-risk,), 4.6% (4/87, intermediate-risk), and 38.9% (75/193, high-risk), respectively. The 5-years overall survival rate was 89.0%. The 5-years recurrent free survival rate (RFS) of gastric GISTs was significantly better than that of other sites’ GISTs (5-years RFS:82.7% vs. 63.9%, P 


We reported the clinicopathological characteristics of GIST in multi-center registry study in Japan. Currently applied GIST risk classification system is comparable to predict high- or low-risk patients with primary non-metastatic and completely resected GIST in pre-IM era.

Clinical trial identification

Legal entity responsible for the study

Kinki GIST registry


Kinki GIST registry


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.