Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

2534 - Change of patient perceptions of chemotherapy side effects in breast and ovarian cancer patients

Date

10 Sep 2017

Session

Poster display session

Topics

Supportive Care and Symptom Management;  Bioethical Principles and GCP;  Therapy;  Ovarian Cancer;  Breast Cancer

Presenters

Beyhan Ataseven

Citation

Annals of Oncology (2017) 28 (suppl_5): v605-v649. 10.1093/annonc/mdx440

Authors

B. Ataseven1, J. Frindte1, P. Harter1, G. Göke1, J. Holtschmidt2, C. Vogt1, A. Traut1, B. Vincenzo2, M. Vincent2, H. Florian1, S. Kuemmel2, S. Prader1, M. Sporkmann1, S. Schneider1, A. du Bois1

Author affiliations

  • 1 Gynecology And Gynecologic Oncology, Kliniken Essen Mitte Evang. Huyssens-Stiftung, 45136 - Essen/DE
  • 2 Breast Unit, Kliniken Essen Mitte Evang. Huyssens-Stiftung, 45136 - Essen/DE
More

Resources

Abstract 2534

Background

Previous studies demonstrated changes of patient perceptions (PP) and individual ranking of chemotherapy side effects (CSE) between 1983-2002. We updated this survey and evaluated changes in PP in comparison to previous studies and as longitudinal observation.

Methods

Patients with breast (BC) and ovarian cancer (OC) planned for chemotherapy were recruited in this prospective study. At three different visits (before (T1), week 12+/-3 (T2), and at the end of chemotherapy (T3)) patients were asked to identify out of 72 cards, displaying potential physical and non-physical CSE, the ten most burdensome and rank them finally to top five by severity.

Results

In total, 141 patients (95 BC and 45 OC) were recruited. All three interviews were completed in 113 patients. The most severe CSE reported was “difficulty sleeping” compared to “vomiting” in 1983, “nausea” in 1993, and “affects my family/partner” in 2002 (Table 1a). “Loss of hair” remained a top concern over all studies. Over the complete observation period “affects my family/partner” and “difficulty sleeping” were among the top five severe side effects. “Feeling of not coping” and “nausea” were ranked only at T1, but not at T2/T3. “Loss of hair” was ranked at T1/T2, but no longer at T3. In contrast, “numbness in limbs” became relevant in T2/T3 (Table 1b).

Conclusions

Patient perceptions of CSE have changed markedly compared with previous studies. However, “loss of hair” has remained an unsolved problem over decades. Furthermore, we demonstrated that PP of CSE changes over the treatment period. However, social concerns like “affecting family/partner” remain long-lasting problems.

Clinical trial identification

Legal entity responsible for the study

Beyhan Ataseven

Funding

None

Disclosure

All authors have declared no conflicts of interest.Table:

1472P_PR

Table 1a Ranking of side effects1983 (Coates et al.)1993 (Griffin et al.)2002 (Carelle et al.)2016 Current study
1VomitingNauseaAffects my family or partnerDifficulty sleeping
2NauseaConstantly tiredLoss of hairAffects my family or partner
3Loss of hairLoss of hairConstantly tiredLoss of hair
4Thought of coming treatmentThought of coming for treatmentAffects my work, home dutiesNumbness in limbs
5Length of time treatment takes at clinicVomitingAffects my social activitiesShortness of breath
Table 1b RankingT1 (before initiation of chemotderapy)T2 (after 12+/-3 w weeks of chemotderapy start)T3 (end of chemotderapy + /- 2 weeks)
1Affects my family or partnerDifficulty sleepingDifficulty sleeping
2Feeling of not coping with treatmentAffects my family or partnerAffects my family or partner
3Loss of hairNumbness in limbsNumbness in limbs
4NauseaLoss of hairAffects my work, home duties
5Difficulty sleepingShortness of breathPins and needles in limbs (fingers, toes)

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.