Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

5194 - CASP9 c.-1339A>G and CASP3 c.-1191A>G polymorphisms in susceptibility and outcome of head and neck squamous cell carcinoma


10 Sep 2017


Poster display session


Cancers in Adolescents and Young Adults (AYA);  Translational Research;  Head and Neck Cancers


Ericka Costa


Annals of Oncology (2017) 28 (suppl_5): v372-v394. 10.1093/annonc/mdx374


E.F.D. Costa1, L. Lopes-Aguiar1, G.A.S. Nogueira1, T.R.P. Lima1, V.T. Liutti1, F. Leal1, V.C.A. Santos1, J.A. Rinck-Junior1, G.J. Lourenço1, C.S.P. Lima2

Author affiliations

  • 1 Department Of Internal Medicine, University of Campinas, 13083-970 - Campinas/BR
  • 2 Department Of Internal Medicine, University of Campinas, 13083-888 - Campinas/BR


Abstract 5194


We analyzed herein the roles of CASP9 c.-1339A>G (rs4645978) and CASP3 c.-1191A>G (rs12108497) single nucleotide polymorphisms (SNPs) of intrinsic apoptosis pathway on risk and behavior of head and neck squamous cell carcinoma (HNSCC).


DNA of 350 HNSCC patients and 350 controls was analyzed by polymerase chain reaction method and enzymatic digestion for genotyping. Patients were treated according to the Institutional protocol, including surgery, radio and chemotherapy. The statistical analyses were realized using chi-square, logistic regression model, multifactor dimensionality reduction (MDR), Kaplan-Meier, and univariate and multivariate Cox analyses.


CASP3 c.-1191AG or GG genotype was more common in patients with overall HNSCC (63.4% versus 53.4%, P= 0.013), male patients with overall HNSCC (65.5% versus 53.4%, P= 0.011), patients with SCC of oral cavity (OCSCC) (68.0% versus 53.4%, P= 0.02) and SCC of pharynx (PSCC) (62.7% versus 53.4%, P =  0.010) than in controls; carriers of genotypes were under 2.15 and 2.34-fold increased risks of overall HNSCC, 2.75 and 2.67-fold increased risks of OCSCC and PSCC, respectively. Interactions of CASP9 and CASP3 SNPs and tobacco on HNSCC, OCSCC, PSCC, and laryngeal SCC risks were evident in study (P< 0.01). At 60 months of follow-up, event-free survival was worst in patients with CASP9 c.-1339GG genotype (35.9% versus 45.1%, P =  0.04) compared to others (Kaplan-Meier estimates). Patients with CASP9 c.-1339GG genotype and CASP9 c.-1339GG plus CASP3 c.-1191GG genotypes had 1.46 more chances of disease progression or relapse and 2.66 more chances of evolving to death in univariate and multivariate analyses, respectively.


We present, for the first time, preliminary evidence that inherited abnormalities in the intrinsic apoptosis pathway, related to CASP9 c.-1339A>G and CASP3 c.-1191A>G SNPs, are important determinants of HNSCC risk and outcome. Financial support: Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP).

Clinical trial identification

Legal entity responsible for the study

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)




All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.