This study is to develop and validate a new classification for nasopharyngeal carcinoma (NPC).
Fifteen hundred and twenty-eight (1528) newly diagnosed NPC patients treated between 1995 and 2010 were included in this study. Seven hundred and one patients (n = 701) were treated with 3D conformal radiotherapy (3D-RT) and 827 patients were treated with IMRT. Cox proportional hazards model was used to select the significant split node to partition patients into the different risk group. Recursive partitioning analysis derived a new classification in patients treated with 3D-RT objectively. This new staging system was then validated in patients treated with IMRT.
The median follow-up interval was 84.6 months (ranging 2-175 months). According to the 7th AJCC staging system, the stage I patients showed a 5-year overall survival (OS) rate of 93.0%, stage II of 94.5%, stage III of 87.5%, stage IVA of 71.5%, stage IVB of 61.3%, and stage IVC of 5.8% (p
We propose a new staging system for NPC, which distributes more patients in the early stage.Table:
1054PD Patient Distribution According to Chinese 2008 and the 7th AJCC staging systems
|Stage||Chinese 2008 staging||2010 AJCC staging||Current proposal|
Clinical trial identification
Legal entity responsible for the study
Koo Foundation Sun Yat-Sen Cancer Center
All authors have declared no conflicts of interest.