Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

5298 - Tumor microenvironment in high serous ovary cancer: characterization of the infiltration pattern and analysis of its prognostic value

Date

09 Sep 2017

Session

Poster display session

Presenters

Franklin Herrera Cañizares

Citation

Annals of Oncology (2017) 28 (suppl_5): v330-v354. 10.1093/annonc/mdx372

Authors

F. Herrera Cañizares1, A. Chipirliu2, C. Caballero3, A. HERREROS POMARES4, S. Calabuig Fariñas5, L. Valdivieso6, M. Mosqueda7, J. Marí Alexandre8, E. Jantus9, J. Gilabert10, C. Camps Herrero11

Author affiliations

  • 1 Laboratorio De Oncología Molecular, Fundación de Investigación Hospital General Universitario de Valencia. Fundación Carolina-BBVA, 46014 - Valencia/ES
  • 2 Servicio De Ginecologia, Hospital General Universitario Valencia, 46014 - VALENCIA/ES
  • 3 Servicio De Oncología Médica, Hospital General Universitario Valencia, 46014 - VALENCIA/ES
  • 4 Laboratorio De Oncología Molecular, Fundación de Investigación Hospital General Universitario de Valencia, 46014 - Valencia/ES
  • 5 Laboratorio De Oncología Molecular, Fundación Para La Investigación, Hospital General Universitario De Valencia-ciberonc;, Departamento de Patología, Universitat de València., 46020 - Valencia/ES
  • 6 Anatomía Patologica, Hospital General Universitario Valencia, 46018 - Valencia/ES
  • 7 Laboratorio De Oncología Molecular, Fundación para la Investigación, Hospital General Universitario de Valencia, 46020 - Valencia/ES
  • 8 Hospital Universitario Y Politécnica La Fe De Valencia, IIS La Fe, Valencia, 46017 - Valencia/ES
  • 9 Laboratorio De Oncología Molecular, Fundación Para La Investigación, Hospital General Universitario De Valencia-ciberonc;, Departamento de Biotecnología, Universidad Politécnica de Valencia, 46014 - Valencia/ES
  • 10 Servicio De Ginecologia, Hospital General Universitario Valencia, 46014 - València/ES
  • 11 Laboratorio De Oncología Molecular, Fundación Para La Investigación, Hospital General Universitario De Valencia. Ciberonc, Servicio de Oncología Médica, Hospital Hospital General Universitario de Valencia; Departamento de Medicina, Universidad de Valencia, 46018 - Valencia/ES
More

Resources

Abstract 5298

Background

Lymphocytic infiltration areas (immunoreactive) are frequently found in ovarian cancer, which is associated with a better prognosis and increased survival. Therefore, the study of different patterns and degree of infiltration would help us to better understand the relationship between immune and tumor cells and its prognostic implications.

Methods

This retrospective study includes samples from 57 patients with high grade serous ovarian cancer (HGSOC) who underwent cytoreductive surgery. The pattern of infiltration, localization and degree of lymphocyte infiltration in the tumor was evaluated. A set of clinical variables such as smoking, age, type of surgery, intention of treatment, type of response, as well as lymphocytic infiltration were evaluated to assess prognosis.

Results

In our cohort, the median age was 61.5 years, there were 60% of smokers, and most of the cases were FIGO stages III and IV (15.3%, stage I, 8.5% stage II, 54.3% stage III and 22% stage IV). As expected, patients over 65 years, as well as the group of more advanced stages (III and IV) showed a shorter overall survival (OS, 30.17 vs 99.90 months, p = 0.009; 38.73 months vs NR, p = 0.005, respectively). Smoking status was also analyzed but no significant effect on survival was found (OS, p = 0.935). Interestingly, patients with an intratumoral lymphocyte infiltrate had better prognosis compared to the group that had only a peritumoral pattern (OS, 44.57 months vs NR, p = 0.041). In addition, those with a diffuse infiltration pattern presented a better prognosis compared to those with a focal pattern (OS, 20.20 months vs NR p = 0.003). Finally, a tendency for a better OS was seen for those patients with a strong degree of infiltration in the tumor.

Conclusions

HGSOC represents a group of highly immunoreactive tumors. Those with the best prognosis are represented by an intratumoral, diffuse pattern with a strong degree of infiltration, these findings could open a new window for therapeutic approaches in HGSOC.

Clinical trial identification

Legal entity responsible for the study

Fundación de Investigación Hospital General de Valenecia

Funding

None

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.