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Poster display session

3946 - The Prognostic Role of Indicators of Systemic Inflammatory Response in Patients with Glioblastoma

Date

10 Sep 2017

Session

Poster display session

Presenters

Vildan Kaya

Citation

Annals of Oncology (2017) 28 (suppl_5): v109-v121. 10.1093/annonc/mdx366

Authors

V. Kaya1, M. Yildirim2, G. Yazıcı3, A.Y. Yalçın4, N. Orhan5, A. Güzel6

Author affiliations

  • 1 Department Of Radiation Oncology, Medstar Antalya Hospital, 07000 - Antalya/TR
  • 2 İnternal Medicine, Bahçeşehir Üniversitesi, 27090 - Gaziantep/TR
  • 3 Department Of Radiation Oncology, Hacettepe University, Ankrar/TR
  • 4 Department Of Radiation Oncology, Suleyman Demirel University, Isparta/TR
  • 5 Department Of Biochemistry, Medicalpark Gaziantep Hospital, Gaziantep/TR
  • 6 Department Of Neurosurgery, Bahçeşehir Üniversitesi, 27090 - Gaziantep/TR
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Resources

Abstract 3946

Background

High-grade gliomas, among which glioblastomas are the most frequently observed histologic subtype, are the most common primary brain tumors in adults. The standard treatment for glioblastoma consists of maximal safe resection, followed by concomitant chemoradiotherapy. It was reported that inflammatory response plays a major role in malignancy, including tumor progression. This study aimed to determine the prognostic role of the neutrophil to lymphocyte ratio (NLR) and the thrombocyte to lymphocyte ratio (PLR)—both indicators of systemic inflammatory response (SIR)—in patients with glioblastoma.

Methods

This study retrospectively evaluated 90 patients that were treated for glioblastoma.

Results

Median follow-up time was 11.3 months (range: 1-70 months). The 1-year and 2-year overall survival rates were 55.2% and 19.5%, respectively. Univariate analysis showed that there wasn’t a correlation between overall survival and gender (p = 0.184), comorbid diseases (p = 0.30), clinical presentation (p = 0.884), or tumor lateralization (p = 0.159). The prognostic factors that affected survival—other than SIR—were Eastern Cooperative Oncology Group (ECOG) performance status (p = 0.003), and tumor localization (p = 0.006). Multivariate analysis showed that overall survival was significantly correlated with SIR based on NLR (HR: 2.41), and ECOG performance status (HR: 1.53).

Conclusions

These findings confirm that the NLR value obtained from peripheral blood prior to treatment can be used as a prognostic factor in patients with glioblastoma. It is known that a high NLR value (NLR ≥5) is indicative of aggressive disease with decreased survival; therefore, aggressive treatment modalities can be offered to this selected patient population.

Clinical trial identification

Legal entity responsible for the study

Mustafa Yıldırım

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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