The aim of this study is to investigate the prognostic significance of the preoperative blood lymphocyte-to-monocyte ratio (LMR) in gastric neuroendocrine neoplasms (g-NENs).
We enrolled 177 patients who had been diagnosed with g-NENs and undergone radical surgery. Receiver operating characteristic curve analysis was used to identify the optimal value for the LMR. Univariate and multivariate survival analyses were used to identify prognostic factors. A nomogram was adopted to predict recurrence free survival (RFS) and overall survival (OS) after surgery.
The LMR was significantly lower in patients with g-NENs than in matched normal volunteers (NVs) (P
As an independent prognostic factor for survivals in patients with g-NENs, the LMR combined with the lymph node ratio and histological type had a more superior ability to predict clinical outcomes in post-surgery patients than the traditional TNM staging system. Patients with low LMRs require close surveillance to identify tumor recurrence early.
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All authors have declared no conflicts of interest.