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Poster display session

5302 - Systematic inflammation and histologic grade in non small cell lung carcinoma

Date

09 Sep 2017

Session

Poster display session

Presenters

Konstantinos Tsapakidis

Citation

Annals of Oncology (2017) 28 (suppl_5): v460-v496. 10.1093/annonc/mdx380

Authors

K. Tsapakidis1, N. Tsoukalas2, C. Giaginis3, I. Gioulbasanis2, M. Tolia1, E. Aravantinou4, M. Galanopoulos3, M. Kiakou3, I. Kostakis3, I. Litos1, M. Liontos5, E. Sogka1, V. Tzouda6, K. Liaskonis3, S. Theocharis3

Author affiliations

  • 1 Medical Oncology, University Hospital of Larissa, 41110 - Larissa/GR
  • 2 Oncology, 417 NIMTS Veterans Hospital, 11521 - Athens/GR
  • 3 First Department Of Pathology, Medical School, National and Kapodistrian University of Athens,, Athens/GR
  • 4 On Behalf Of The Hellenic Group Of Young Oncologists (hegyo, Http://www.hesmo.gr/en/gyon/group), Under The Auspices Of The Hellenic Society Of Medical Oncology (hesmo, Http://www.hesmo.gr/en), On behalf of the Hellenic Group of Young Oncologists (HeGYO, http://www.hesmo.gr/en/gyon/group), under the auspices of the Hellenic Society of Medical Oncology (HeSMO, http://www.hesmo.gr/en), 11524 - Athens/GR
  • 5 Clinical Therapeutics, General Hospital Alexandra, National and Kapodistrian University of Athens, 11528 - Athens/GR
  • 6 Medical Oncology, Agios Savvas Regional Cancer Hospital, 115 22 - Athens/GR
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Resources

Abstract 5302

Background

Tumor grade is an important factor of cancer outcome. Systematic inflammation has been associated with tumorigenesis and tumor aggressiveness and prognosis in several human malignancies. Cancer cells create an inflammatory peritumoral microenviroment by releasing a number of cytokines.

Methods

In total, 100 patients (88 males) with histologically proven NSCLC and no signs of active infection were evaluated. Tumor grade was examined and systematic inflammatory response was assessed by circulating levels of C-reactive protein (CRP), albumin, ferritin, transferring and the modified Glasgow Prognostic Score (mGPS). Patients were followed up and survival data were subsequently collected. Associations with clinicopathological, histological parameters and patients’ survival were studied.

Results

Histological grade was associated with tumor size, the presence of pathological lymph nodes, organ metastases and advanced disease stage (p = 0.010, p 

Conclusions

Our data support the association of tumour grade with the presence of systemic inflammation; two well described negative prognostic factors for NSCLC. To our knowledge this is the first time that these factors are associated with each other giving more information about the prognosis in patients with NSCLC.

Clinical trial identification

Legal entity responsible for the study

None

Funding

None

Disclosure

All authors have declared no conflicts of interest.

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