Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session

5302 - Systematic inflammation and histologic grade in non small cell lung carcinoma


09 Sep 2017


Poster display session


Konstantinos Tsapakidis


Annals of Oncology (2017) 28 (suppl_5): v460-v496. 10.1093/annonc/mdx380


K. Tsapakidis1, N. Tsoukalas2, C. Giaginis3, I. Gioulbasanis2, M. Tolia1, E. Aravantinou4, M. Galanopoulos3, M. Kiakou3, I. Kostakis3, I. Litos1, M. Liontos5, E. Sogka1, V. Tzouda6, K. Liaskonis3, S. Theocharis3

Author affiliations

  • 1 Medical Oncology, University Hospital of Larissa, 41110 - Larissa/GR
  • 2 Oncology, 417 NIMTS Veterans Hospital, 11521 - Athens/GR
  • 3 First Department Of Pathology, Medical School, National and Kapodistrian University of Athens,, Athens/GR
  • 4 On Behalf Of The Hellenic Group Of Young Oncologists (hegyo, Http://www.hesmo.gr/en/gyon/group), Under The Auspices Of The Hellenic Society Of Medical Oncology (hesmo, Http://www.hesmo.gr/en), On behalf of the Hellenic Group of Young Oncologists (HeGYO, http://www.hesmo.gr/en/gyon/group), under the auspices of the Hellenic Society of Medical Oncology (HeSMO, http://www.hesmo.gr/en), 11524 - Athens/GR
  • 5 Clinical Therapeutics, General Hospital Alexandra, National and Kapodistrian University of Athens, 11528 - Athens/GR
  • 6 Medical Oncology, Agios Savvas Regional Cancer Hospital, 115 22 - Athens/GR


Abstract 5302


Tumor grade is an important factor of cancer outcome. Systematic inflammation has been associated with tumorigenesis and tumor aggressiveness and prognosis in several human malignancies. Cancer cells create an inflammatory peritumoral microenviroment by releasing a number of cytokines.


In total, 100 patients (88 males) with histologically proven NSCLC and no signs of active infection were evaluated. Tumor grade was examined and systematic inflammatory response was assessed by circulating levels of C-reactive protein (CRP), albumin, ferritin, transferring and the modified Glasgow Prognostic Score (mGPS). Patients were followed up and survival data were subsequently collected. Associations with clinicopathological, histological parameters and patients’ survival were studied.


Histological grade was associated with tumor size, the presence of pathological lymph nodes, organ metastases and advanced disease stage (p = 0.010, p 


Our data support the association of tumour grade with the presence of systemic inflammation; two well described negative prognostic factors for NSCLC. To our knowledge this is the first time that these factors are associated with each other giving more information about the prognosis in patients with NSCLC.

Clinical trial identification

Legal entity responsible for the study





All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.